Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature
- PMID: 33614496
- PMCID: PMC7890025
- DOI: 10.3389/fonc.2020.612802
Endothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature
Abstract
Solid tumors are dependent on vascularization for their growth. The hypoxic, stiff, and pro-angiogenic tumor microenvironment induces angiogenesis, giving rise to an immature, proliferative, and permeable vasculature. The tumor vessels promote tumor metastasis and complicate delivery of anti-cancer therapies. In many types of tumors, YAP/TAZ activation is correlated with increased levels of angiogenesis. In addition, endothelial YAP/TAZ activation is important for the formation of new blood and lymphatic vessels during development. Oncogenic activation of YAP/TAZ in tumor cell growth and invasion has been studied in great detail, however the role of YAP/TAZ within the tumor endothelium remains insufficiently understood, which complicates therapeutic strategies aimed at targeting YAP/TAZ in cancer. Here, we overview the upstream signals from the tumor microenvironment that control endothelial YAP/TAZ activation and explore the role of their downstream targets in driving tumor angiogenesis. We further discuss the potential for anti-cancer treatments and vascular normalization strategies to improve tumor therapies.
Keywords: Angiogenic therapy; TAZ; cancer; endothelium; mechanotransduction; tumor angiogenesis; tumor vasculature; yes-associated protein (YAP).
Copyright © 2021 Hooglugt, van der Stoel, Boon and Huveneers.
Conflict of interest statement
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
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