LDL receptors and their role in targeted therapy for glioma: a review

doi:10.1016/j.drudis.2021.02.008

Review

. 2021 May;26(5):1212-1225.

doi: 10.1016/j.drudis.2021.02.008. Epub 2021 Feb 18.

LDL receptors and their role in targeted therapy for glioma: a review

Shreya Pawar¹, Tejaswi Koneru², Eva McCord³, Katyayani Tatiparti⁴, Samaresh Sau⁴, Arun K Iyer⁵

Affiliations

¹ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Troy High School, Troy, MI 48098, USA.
² Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Walled Lake Central High School, Commerce Charter Township, MI 48390, USA.
³ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Grosse Pointe South High School, Grosse Pointe Farms, MI 48236, USA.
⁴ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
⁵ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Molecular Imaging Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA. Electronic address: arun.iyer@wayne.edu.

PMID: 33609780
DOI: 10.1016/j.drudis.2021.02.008

Review

LDL receptors and their role in targeted therapy for glioma: a review

Shreya Pawar et al. Drug Discov Today. 2021 May.

. 2021 May;26(5):1212-1225.

doi: 10.1016/j.drudis.2021.02.008. Epub 2021 Feb 18.

Authors

Shreya Pawar¹, Tejaswi Koneru², Eva McCord³, Katyayani Tatiparti⁴, Samaresh Sau⁴, Arun K Iyer⁵

Affiliations

¹ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Troy High School, Troy, MI 48098, USA.
² Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Walled Lake Central High School, Commerce Charter Township, MI 48390, USA.
³ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Grosse Pointe South High School, Grosse Pointe Farms, MI 48236, USA.
⁴ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA.
⁵ Use-inspired Biomaterials & Integrated Nano Delivery (U-BiND) Systems Laboratory, Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI 48201, USA; Molecular Imaging Program, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA. Electronic address: arun.iyer@wayne.edu.

PMID: 33609780
DOI: 10.1016/j.drudis.2021.02.008

Abstract

Gliomas are highly lethal forms of cancers occurring in the brain. Delivering the drugs into the brain is a major challenge to the treatment of gliomas because of the highly selectively permeable blood-brain barrier (BBB). Tapping the potential of receptor-mediated drug delivery systems using targeted nanoparticles (NPs) is a sought-after step forward toward successful glioma treatment. Several receptors are the focus of research for application in drug delivery. Low-density lipoprotein receptors (LDLR) are abundantly expressed in both healthy brains and diseased brains with a disrupted BBB. In this review, we discuss the LDLR and the types of NPs that have been used to target the brain via this receptor.

PubMed Disclaimer

Cited by

Counteracting Immunosenescence-Which Therapeutic Strategies Are Promising?
Hieber C, Grabbe S, Bros M. Hieber C, et al. Biomolecules. 2023 Jul 6;13(7):1085. doi: 10.3390/biom13071085. Biomolecules. 2023. PMID: 37509121 Free PMC article. Review.
Uptake of lipid core nanoparticles by fragments of tissues collected during cerebral tumor excision surgeries: hypotheses for use in drug targeting therapy.
Pereira ELR, Feio DCA, Tavares JPL, Morikawa NM, Deus DF, Vital CG, Tavares ER, Maranhão RC. Pereira ELR, et al. J Neurooncol. 2022 Jul;158(3):413-421. doi: 10.1007/s11060-022-04028-1. Epub 2022 May 25. J Neurooncol. 2022. PMID: 35612697
Molecular Determinants for Photodynamic Therapy Resistance and Improved Photosensitizer Delivery in Glioma.
Aebisher D, Woźnicki P, Czarnecka-Czapczyńska M, Dynarowicz K, Szliszka E, Kawczyk-Krupka A, Bartusik-Aebisher D. Aebisher D, et al. Int J Mol Sci. 2024 Aug 9;25(16):8708. doi: 10.3390/ijms25168708. Int J Mol Sci. 2024. PMID: 39201395 Free PMC article. Review.
Probing the affinity of noble metal nanoparticles to the segments of the SARS-CoV-2 spike protein.
Lu Q, Zhang B, Sun M, Lu L, Chen B, Wong HH, Chan CH, Wu T, Huang B. Lu Q, et al. iScience. 2023 Mar 17;26(3):106110. doi: 10.1016/j.isci.2023.106110. Epub 2023 Feb 4. iScience. 2023. PMID: 36776935 Free PMC article.
How Precise are Nanomedicines in Overcoming the Blood-Brain Barrier? A Comprehensive Review of the Literature.
Mohapatra P, Gopikrishnan M, Doss C GP, Chandrasekaran N. Mohapatra P, et al. Int J Nanomedicine. 2024 Mar 8;19:2441-2467. doi: 10.2147/IJN.S442520. eCollection 2024. Int J Nanomedicine. 2024. PMID: 38482521 Free PMC article. Review.

See all "Cited by" articles

Publication types

Actions
Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

R21 CA179652/CA/NCI NIH HHS/United States

LinkOut - more resources

Full Text Sources
- Elsevier Science
Other Literature Sources
- scite Smart Citations
Medical
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

LDL receptors and their role in targeted therapy for glioma: a review

Affiliations

LDL receptors and their role in targeted therapy for glioma: a review

Authors

Affiliations

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Similar articles

Cited by

Publication types

MeSH terms

Substances

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical