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Review
. 2021 Jan 5;35(1):80-84.
doi: 10.13201/j.issn.2096-7993.2021.01.021.

[Effect of CCR3 gene on related inflammatory cells in respiratory allergic diseases]

[Article in Chinese]
Saiyi Tang, Xinhua Shu
Review

[Effect of CCR3 gene on related inflammatory cells in respiratory allergic diseases]

[Article in Chinese]
Saiyi Tang et al. Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. .

Abstract

Respiratory allergic disease mainly include asthma and allergic rhinitis.According to their extremely similarpathogenesis and inflammatory pathological changes,asthma and allergic rhinitis,are regarded as the concept of "one airway, one disease". In recent years, The research on the target of allergens in the pathogenesis mechanism is more in-depth, and the CCR3 gene is a major research target. The study found that the CCR3 gene is an important target gene for the development of respiratory allergic diseases such as allergic rhinitis and asthma. The related inflammatory cells are the main cells responding for the downstream cascade triggered by CCR3 activation, which directly or indirectly cause allergic inflammation through itself or its secretions.Therefore, researches on the roles of CCR3 gene and its related inflammatory cells become hot topics in the clinical treatment of respiratory allergic diseases. This paper reviews the current research progress of respiratory allergic diseases on the basis of intensive literature.

Keywords: CCR3; basophils; eosinophils; mast cells; respiratory allergic disease.

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Conflict of interest statement

The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.

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Grants and funding

国家自然科学基金项目(No：81860184)；江西省优势科技创新团队专项计划(No：S2016RCTDB0016)；江西省卫生厅项目计划(No：20155338)