Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 Jan;57(1):27-35.
doi: 10.4068/cmj.2021.57.1.27. Epub 2021 Jan 25.

Liposomes: Biomedical Applications

Eun-Mi Kim  1 , Hwan-Jeong Jeong  1
Affiliations
Review

Liposomes: Biomedical Applications

Eun-Mi Kim et al. Chonnam Med J. 2021 Jan.

Abstract

Liposomes, with their flexible physicochemical and biophysical properties, continue to be studied as an important potential a critical drug delivery system. Liposomes have overcome the challenges of conventional free drug therapy by encapsulating therapeutic agents, thereby improving in vivo biodistribution and reducing systemic toxicity. New imaging modalities and interpretation techniques, as well as new techniques for targetable system formulation technique, and tumor environmental information, have affected the search for a means of overcoming the difficulties of conventional liposome formulation. In this review, we briefly discuss how liposomal formulation has been applied across the biomedical field, particularly as a therapy, and the role it may play in the future, when paired with new developments in diagnosis and theranostics. The biological challenges that still remain and the translational obstacles are discussed.

Keywords: Drug Delivery Systems; Liposomes; Neoplasms; Precision Medicine.

PubMed Disclaimer

Conflict of interest statement

CONFLICT OF INTEREST STATEMENT: None declared.

Figures

FIG. 1
FIG. 1. Liposome (A) and micelle (B) structure.
FIG. 2
FIG. 2. Structure of MLV (A), LUV (B), and SUV (C). MLV: multilamellar vesicles, LUV: large unilamellar vesicles, SUV: small unilamellar vesicles.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Mohanty A, Uthaman S, Park IK. Utilization of polymer-lipid hybrid nanoparticles for targeted anti-cancer therapy. Molecules. 2020;25:4377 - PMC - PubMed
    1. Yuba E. Development of functional liposomes by modification of stimuli-responsive materials and their biomedical applications. J Mater Chem B. 2020;8:1093–1107. - PubMed
    1. Bozzuto G, Molinari A. Liposomes as nanomedical devices. Int J Nanomedicine. 2015;10:975–999. - PMC - PubMed
    1. Beltrán-Gracia E, López-Camacho A, Higuera-Ciapara I, VelázquezFernández JB, Vallejo-Cardona AA. Nanomedicine review: clinical developments in liposomal applications. Cancer Nanotechnol. 2019;10:11
    1. He H, Lu Y, Qi J, Zhu Q, Chen Z, Wu W. Adapting liposomes for oral drug delivery. Acta Pharm Sin B. 2019;9:36–48. - PMC - PubMed