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Review
. 2021 Jan 7;27(1):37-54.
doi: 10.3748/wjg.v27.i1.37.

Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review

Khaled Mohamed Mohamed Koriem  1
Affiliations
Review

Lipidome is lipids regulator in gastrointestinal tract and it is a life collar in COVID-19: A review

Khaled Mohamed Mohamed Koriem. World J Gastroenterol. .

Abstract

The term lipidome is mentioned to the total amount of the lipids inside the biological cells. The lipid enters the human gastrointestinal tract through external source and internal source. The absorption pathway of lipids in the gastrointestinal tract has many ways; the 1st way, the lipid molecules are digested in the lumen before go through the enterocytes, digested products are re-esterified into complex lipid molecules. The 2nd way, the intracellular lipids are accumulated into lipoproteins (chylomicrons) which transport lipids throughout the whole body. The lipids are re-synthesis again inside the human body where the gastrointestinal lipids are: (1) Transferred into the endoplasmic reticulum; (2) Collected as lipoproteins such as chylomicrons; or (3) Stored as lipid droplets in the cytosol. The lipids play an important role in many stages of the viral replication cycle. The specific lipid change occurs during viral infection in advanced viral replication cycle. There are 47 lipids within 11 lipid classes were significantly disturbed after viral infection. The virus connects with blood-borne lipoproteins and apolipoprotein E to change viral infectivity. The viral interest is cholesterol- and lipid raft-dependent molecules. In conclusion, lipidome is important in gastrointestinal fat absorption and coronavirus disease 2019 (COVID-19) infection so lipidome is basic in gut metabolism and in COVID-19 infection success.

Keywords: COVID-19; Fat metabolism; Future therapy; Gastrointestinal tract; Lipidome; Viral infection.

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Conflict of interest statement

Conflict-of-interest statement: The author declares no conflict of interest.

Figures

Figure 1
Figure 1
Different types of omics.
Figure 2
Figure 2
Lipidome and COVID-19 in gastrointestinal tract.
See this image and copyright information in PMC

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References

    1. Züllig T, Trötzmüller M, Köfeler HC. Lipidomics from sample preparation to data analysis: a primer. Anal Bioanal Chem. 2020;412:2191–2209. - PMC - PubMed
    1. Schlame M, Xu Y, Erdjument-Bromage H, Neubert TA, Ren M. Lipidome-wide 13C flux analysis: a novel tool to estimate the turnover of lipids in organisms and cultures. J Lipid Res. 2020;61:95–104. - PMC - PubMed
    1. Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH, Bandyopadhyay S, Jones KN, Kelly S, Shaner RL, Sullards CM, Wang E, Murphy RC, Barkley RM, Leiker TJ, Raetz CR, Guan Z, Laird GM, Six DA, Russell DW, McDonald JG, Subramaniam S, Fahy E, Dennis EA. Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res. 2010;51:3299–3305. - PMC - PubMed
    1. Koriem KMM. A lipidomic concept in infectious diseases. Asian Pac J Trop Biomed . 2017; 7:265–274.
    1. Koriem KMM. Protective effect of natural products and hormones in colon cancer using metabolome: A physiological overview. Asian Pac J Trop Biomed. 2017;7:957–966.