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Comparative Study
. 2021 May:232:287-289.e4.
doi: 10.1016/j.jpeds.2021.01.027. Epub 2021 Jan 21.

Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

Serena Villaverde  1 , Sara Domínguez-Rodríguez  2 , Gema Sabrido  3 , Conchita Pérez-Jorge  4 , Marta Plata  5 , María Pilar Romero  6 , Carlos Daniel Grasa  7 , Ana Belén Jiménez  8 , Elena Heras  8 , Antonio Broncano  9 , María Del Mar Núñez  10 , Marta Illán  11 , Paloma Merino  12 , Beatriz Soto  13 , David Molina-Arana  14 , Amanda Bermejo  15 , Pablo Mendoza  16 , Manuel Gijón  17 , Begoña Pérez-Moneo  18 , Cinta Moraleda  19 , Alfredo Tagarro  20 ; Epidemiological Study of COVID-19 in Children of the Spanish Society of Pediatric (EPICO-AEP) Working Group
Collaborators, Affiliations
Comparative Study

Diagnostic Accuracy of the Panbio Severe Acute Respiratory Syndrome Coronavirus 2 Antigen Rapid Test Compared with Reverse-Transcriptase Polymerase Chain Reaction Testing of Nasopharyngeal Samples in the Pediatric Population

Serena Villaverde et al. J Pediatr. 2021 May.

Abstract

We conducted a multicenter clinical validity study of the Panbio coronavirus disease 2019 Antigen Rapid Test of nasopharyngeal samples in pediatric patients with coronavirus disease 2019-compatible symptoms of ≤5 days of evolution. Our study showed limited accuracy in nasopharyngeal antigen testing: overall sensitivity was 45.4%, and 99.8% of specificity, positive-predictive value was 92.5%.

Keywords: COVID-19; PCR; SARS-CoV-2; antigen test.

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Figures

Figure 1
Figure 1
Overall sensitivity, specificity, and predictive values for rapid antigenic test Panbio using RT-PCR as the gold-standard reference.
Figure 2
Figure 2
Representation of sensitivity, specificity, and predictive values for rapid antigenic test Panbio using RT-PCR as the gold-standard reference.
See this image and copyright information in PMC

Comment in

  • Diagnostic performance of antigen testing for severe acute respiratory syndrome coronavirus 2.
    Marchán-López Á, Ayuso García B. Marchán-López Á, et al. J Pediatr. 2021 Jun;233:283. doi: 10.1016/j.jpeds.2021.02.052. Epub 2021 Feb 22. J Pediatr. 2021. PMID: 33631167 Free PMC article. No abstract available.
  • Reply.
    Villaverde S, Merino-Amador P, Mendoza P, Molina-Arana D, Romero MP, Moraleda C, Tagarro A. Villaverde S, et al. J Pediatr. 2021 Jun;233:283-284. doi: 10.1016/j.jpeds.2021.02.051. Epub 2021 Feb 22. J Pediatr. 2021. PMID: 33631168 Free PMC article. No abstract available.

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