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Clinical Trial
. 2021 Jan 14;11(1):1416.
doi: 10.1038/s41598-020-80812-1.

Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study

Ban-Hock Khor  1 , Sharmela Sahathevan  2 , Ayesha Sualeheen  2 , Mohammad Syafiq Md Ali  3 , Sreelakshmi Sankara Narayanan  4 , Karuthan Chinna  5 , Abdul Halim Abdul Gafor  1 , Bak-Leong Goh  6 , Ghazali Ahmad  7 , Zaki Morad  8 , Zulfitri Azuan Mat Daud  3 , Pramod Khosla  9 , Kalyana Sundram  10 , Tilakavati Karupaiah  11 ; PaTCH Investigators
Collaborators, Affiliations
Clinical Trial

Circulating fatty acid profiles are associated with protein energy wasting in maintenance hemodialysis patients: a cross-sectional study

Ban-Hock Khor et al. Sci Rep. .

Abstract

The metabolic impact of circulating fatty acids (FAs) in patients requiring hemodialysis (HD) is unknown. We investigated the associations between plasma triglyceride (TG) FAs and markers of inflammation, insulin resistance, nutritional status and body composition. Plasma TG-FAs were measured using gas chromatography in 341 patients on HD (age = 55.2 ± 14.0 years and 54.3% males). Cross-sectional associations of TG-FAs with 13 markers were examined using multivariate linear regression adjusted for potential confounders. Higher levels of TG saturated fatty acids were associated with greater body mass index (BMI, r = 0.230), waist circumference (r = 0.203), triceps skinfold (r = 0.197), fat tissue index (r = 0.150), serum insulin (r = 0.280), and homeostatic model assessment of insulin resistance (r = 0.276), but lower malnutrition inflammation score (MIS, r = - 0.160). Greater TG monounsaturated fatty acid levels were associated with lower lean tissue index (r = - 0.197) and serum albumin (r = - 0.188), but higher MIS (r = 0.176). Higher levels of TG n-3 polyunsaturated fatty acids (PUFAs) were associated with lower MIS (r = - 0.168) and interleukin-6 concentrations (r = - 0.115). Higher levels of TG n-6 PUFAs were associated with lower BMI (r = - 0.149) but greater serum albumin (r = 0.112). In conclusion, TG monounsaturated fatty acids were associated with poor nutritional status, while TG n-3 PUFAs were associated with good nutritional status. On the other hand, TG saturated fatty acids and TG n-6 PUFAs had both favorable and unfavorable associations with nutritional parameters.

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Conflict of interest statement

Co-author K.S. is employed at the Malaysian Palm Oil Council and he has a background in lipid science. Other authors declare that they have no competing interest.

Figures

Figure 1
Figure 1
Flow chart of patient enrollment and analysis in this study.
Figure 2
Figure 2
Correlation matrices between triglyceride fatty acids and biochemical markers, body composition, physical strength, and nutritional status. Correlations are represented by different colour cells: the red scale (r = 0 to − 0.4) indicates negative associations while the green scale (r = 0 to 0.4) indicates positive associations.
See this image and copyright information in PMC

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References

    1. Krane V, Wanner C. Statins, inflammation and kidney disease. Nat. Rev. Nephrol. 2011;7(7):385–391. doi: 10.1038/nrneph.2011.62. - DOI - PubMed
    1. Adamczak M, et al. Diagnosis and treatment of metabolic acidosis in patients with chronic kidney disease–position statement of the working group of the Polish Society of Nephrology. Kidney Blood Press. Res. 2018;43(3):959–969. doi: 10.1159/000490475. - DOI - PubMed
    1. Bazeley J, et al. C-reactive protein and prediction of 1-year mortality in prevalent hemodialysis patients. Clin. J. Am. Soc. Nephrol. 2011;6(10):2452–2461. doi: 10.2215/CJN.00710111. - DOI - PMC - PubMed
    1. Panichi V, et al. Chronic inflammation and mortality in haemodialysis: effect of different renal replacement therapies. Results from the RISCAVID study. Nephrol. Dial. Transplant. 2008;23(7):2337–2343. doi: 10.1093/ndt/gfm951. - DOI - PubMed
    1. Fouque D, et al. A proposed nomenclature and diagnostic criteria for protein–energy wasting in acute and chronic kidney disease. Kidney Int. 2008;73(4):391–398. doi: 10.1038/sj.ki.5002585. - DOI - PubMed

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