Neuroligin-2 as a central organizer of inhibitory synapses in health and disease
- PMID: 33443230
- DOI: 10.1126/scisignal.abd8379
Neuroligin-2 as a central organizer of inhibitory synapses in health and disease
Abstract
Postsynaptic organizational protein complexes play central roles both in orchestrating synapse formation and in defining the functional properties of synaptic transmission that together shape the flow of information through neuronal networks. A key component of these organizational protein complexes is the family of synaptic adhesion proteins called neuroligins. Neuroligins form transsynaptic bridges with presynaptic neurexins to regulate various aspects of excitatory and inhibitory synaptic transmission. Neuroligin-2 (NLGN2) is the only member that acts exclusively at GABAergic inhibitory synapses. Altered expression and mutations in NLGN2 and several of its interacting partners are linked to cognitive and psychiatric disorders, including schizophrenia, autism, and anxiety. Research on NLGN2 has fundamentally shaped our understanding of the molecular architecture of inhibitory synapses. Here, we discuss the current knowledge on the molecular and cellular functions of mammalian NLGN2 and its role in the neuronal circuitry that regulates behavior in rodents and humans.
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.
Similar articles
-
Molecular Mechanism of MDGA1: Regulation of Neuroligin 2:Neurexin Trans-synaptic Bridges.Neuron. 2017 Jun 21;94(6):1132-1141.e4. doi: 10.1016/j.neuron.2017.06.009. Neuron. 2017. PMID: 28641112 Free PMC article.
-
Unique versus Redundant Functions of Neuroligin Genes in Shaping Excitatory and Inhibitory Synapse Properties.J Neurosci. 2017 Jul 19;37(29):6816-6836. doi: 10.1523/JNEUROSCI.0125-17.2017. Epub 2017 Jun 12. J Neurosci. 2017. PMID: 28607166 Free PMC article.
-
Neuroligin 2 deletion alters inhibitory synapse function and anxiety-associated neuronal activation in the amygdala.Neuropharmacology. 2016 Jan;100:56-65. doi: 10.1016/j.neuropharm.2015.06.016. Epub 2015 Jun 30. Neuropharmacology. 2016. PMID: 26142252
-
Neuroligins and neurexins link synaptic function to cognitive disease.Nature. 2008 Oct 16;455(7215):903-11. doi: 10.1038/nature07456. Nature. 2008. PMID: 18923512 Free PMC article. Review.
-
Neuroligins, synapse balance and neuropsychiatric disorders.Pharmacol Rep. 2014 Oct;66(5):830-5. doi: 10.1016/j.pharep.2014.04.011. Epub 2014 May 9. Pharmacol Rep. 2014. PMID: 25149987 Review.
Cited by
-
Neuroligin-2 controls the establishment of fast GABAergic transmission in adult-born granule cells.Hippocampus. 2023 Apr;33(4):424-441. doi: 10.1002/hipo.23505. Epub 2023 Jan 28. Hippocampus. 2023. PMID: 36709408 Free PMC article.
-
Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.Commun Biol. 2024 Sep 17;7(1):1157. doi: 10.1038/s42003-024-06789-z. Commun Biol. 2024. PMID: 39284869 Free PMC article.
-
Modulation of Trans-Synaptic Neurexin-Neuroligin Interaction in Pathological Pain.Cells. 2022 Jun 16;11(12):1940. doi: 10.3390/cells11121940. Cells. 2022. PMID: 35741069 Free PMC article. Review.
-
Reversing anxiety by targeting a stress-responsive signaling pathway.Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2400078121. doi: 10.1073/pnas.2400078121. Epub 2024 Jul 26. Proc Natl Acad Sci U S A. 2024. PMID: 39058580 Free PMC article.
-
Structure, function, and pathology of Neurexin-3.Genes Dis. 2022 Apr 30;10(5):1908-1919. doi: 10.1016/j.gendis.2022.04.008. eCollection 2023 Sep. Genes Dis. 2022. PMID: 37492720 Free PMC article. Review.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
Molecular Biology Databases
