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. 2021 Jan 13;11(1):1036.
doi: 10.1038/s41598-020-80222-3.

Evaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years

Wolfgang List  1 , Wilfried Glatz  2 , Regina Riedl  3 , Georg Mossboeck  2 , Gernot Steinwender  2 , Andreas Wedrich  2
Affiliations

Evaluation of Acanthamoeba keratitis cases in a tertiary medical care centre over 21 years

Wolfgang List et al. Sci Rep. .

Abstract

To report on Acanthamoeba keratitis cases in a tertiary university eye-hospital in Graz, Austria, over a 21-year period. Retrospective study. Parameters included demographics, diagnostics, clinical courses, medical therapies, surgical interventions, secondary complications, and best spectacle-corrected visual acuity (BSCVA). Patient records for 44 eyes of 42 patients were analysed; 2 bilateral infections. Mean age at presentation was 31 ± 13 (16-65) years; contact lenses were used in 41 of 44 eyes (93.2%). Symptoms at initial presentation were mainly pain (41/43, 95.3%) and photophobia (16/43, 37.2%). Most frequent morphological findings were stromal infiltrates (30/44, 68.2%). Diagnosis was mainly confirmed by smears (40/42, 95.2%) and polymerase chain reaction (8/42, 19%). Antiamoebic treatment comprised biguanides and diamidines. Penetrating keratoplasty was performed in 10/44 (22.7%) eyes. Median time from symptom onset to initial visit was 2 (0-26) weeks; median follow-up was 30 (2-1008) weeks. BSCVA improved in 23/36 (63.9%) eyes, remained unchanged in 6/36 (16.7%) eyes and deteriorated in 7/36 (19.4%) eyes. Acanthamoeba keratitis predominantly occurs in young contact lens wearers. Diagnosis should be considered in patients with pain and stromal infiltrates. In the majority of cases, BSCVA can be improved. Early diagnosis and adequate treatment should be implemented to prevent complications.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Figure 1
Figure 1
Acanthamoeba cyst.
Figure 2
Figure 2
Boxplots of best spectacle-corrected visual acuity (BSCVA) courses within the first 12 months measured at initial presentation, after 1 month, after 3 months, after 6 months and after 12 months. The table in the bottom indicates the absolute number (N) of available data, mean value and standard deviation.
Figure 3
Figure 3
OR for the risk factors for poor outcome.
See this image and copyright information in PMC

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