Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months

doi:10.1038/s41423-020-00605-4

. 2021 Feb;18(2):490-491.

doi: 10.1038/s41423-020-00605-4. Epub 2021 Jan 8.

Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months

Pai Peng^#¹, Jie Hu^#¹, Hai-Jun Deng¹, Bei-Zhong Liu², Liang Fang², Kai Wang³, Ni Tang⁴, Ai-Long Huang⁵

Affiliations

¹ Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
² Yong-Chuan Hospital, Chongqing Medical University, Chongqing, 402160, China.
³ Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. wangkai@cqmu.edu.cn.
⁴ Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. nitang@cqmu.edu.cn.
⁵ Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. ahuang@cqmu.edu.cn.

^# Contributed equally.

PMID: 33420358
PMCID: PMC7791534
DOI: 10.1038/s41423-020-00605-4

Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months

Pai Peng et al. Cell Mol Immunol. 2021 Feb.

. 2021 Feb;18(2):490-491.

doi: 10.1038/s41423-020-00605-4. Epub 2021 Jan 8.

Authors

Pai Peng^#¹, Jie Hu^#¹, Hai-Jun Deng¹, Bei-Zhong Liu², Liang Fang², Kai Wang³, Ni Tang⁴, Ai-Long Huang⁵

Affiliations

¹ Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
² Yong-Chuan Hospital, Chongqing Medical University, Chongqing, 402160, China.
³ Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. wangkai@cqmu.edu.cn.
⁴ Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. nitang@cqmu.edu.cn.
⁵ Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. ahuang@cqmu.edu.cn.

^# Contributed equally.

PMID: 33420358
PMCID: PMC7791534
DOI: 10.1038/s41423-020-00605-4

Erratum in

Correction: Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months.
Peng P, Hu J, Deng HJ, Liu BZ, Fang L, Wang K, Tang N, Huang AL. Peng P, et al. Cell Mol Immunol. 2022 Dec;19(12):1440. doi: 10.1038/s41423-022-00915-9. Cell Mol Immunol. 2022. PMID: 36042353 Free PMC article. No abstract available.

No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

**Fig. 1**
Maintenance of the humoral response to SARS-CoV-2 in convalescent patients over 8 months. a Blood samples were collected in February and October. Enzyme-linked immunosorbent assays (ELISAs) (b) and pseudovirus-based neutralizing assays (c) were performed to detect IgG levels and neutralizing antibody (NAb) titers against SARS-CoV-2. The thresholds of detection were 0.26 for the OD₄₅₀ value and 1:40 for the ID₅₀. d Correlation of IgG and NAb levels. e Neutralizing activities of convalescent plasma against SARS-CoV-2 S-D614 or S-G614 mutant at 8 months after symptom onset

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References

1. Ripperger TJ, et al. Orthogonal SARS-CoV-2 serological assays enable surveillance of low prevalence communities and reveal durable humoral immunity. Immunity. 2020 doi: 10.1016/j.immuni.2020.10.004. - DOI - PMC - PubMed
1. Patel MM, et al. Change in antibodies to SARS-CoV-2 over 60 days among health care personnel in Nashville, Tennessee. JAMA. 2020 doi: 10.1001/jama.2020.18796. - DOI - PMC - PubMed
1. Wang K, et al. Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection. Clin. Infect. Dis. 2020 doi: 10.1093/cid/ciaa1143.. - DOI - PMC - PubMed
1. Chen Y, et al. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. Cell. 2020 doi: 10.1016/j.cell.2020.10.051. - DOI - PMC - PubMed
1. To KK-W, et al. COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing. Clin. Infect. Dis. 2020 doi: 10.1093/cid/ciaa1275. - DOI - PMC - PubMed

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[1] Ripperger TJ, et al. Orthogonal SARS-CoV-2 serological assays enable surveillance of low prevalence communities and reveal durable humoral immunity. Immunity. 2020 doi: 10.1016/j.immuni.2020.10.004. - DOI - PMC - PubMed

[2] Ripperger TJ, et al. Orthogonal SARS-CoV-2 serological assays enable surveillance of low prevalence communities and reveal durable humoral immunity. Immunity. 2020 doi: 10.1016/j.immuni.2020.10.004. - DOI - PMC - PubMed

[3] Patel MM, et al. Change in antibodies to SARS-CoV-2 over 60 days among health care personnel in Nashville, Tennessee. JAMA. 2020 doi: 10.1001/jama.2020.18796. - DOI - PMC - PubMed

[4] Patel MM, et al. Change in antibodies to SARS-CoV-2 over 60 days among health care personnel in Nashville, Tennessee. JAMA. 2020 doi: 10.1001/jama.2020.18796. - DOI - PMC - PubMed

[5] Wang K, et al. Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection. Clin. Infect. Dis. 2020 doi: 10.1093/cid/ciaa1143.. - DOI - PMC - PubMed

[6] Wang K, et al. Longitudinal dynamics of the neutralizing antibody response to SARS-CoV-2 infection. Clin. Infect. Dis. 2020 doi: 10.1093/cid/ciaa1143.. - DOI - PMC - PubMed

[7] Chen Y, et al. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. Cell. 2020 doi: 10.1016/j.cell.2020.10.051. - DOI - PMC - PubMed

[8] Chen Y, et al. Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production. Cell. 2020 doi: 10.1016/j.cell.2020.10.051. - DOI - PMC - PubMed

[9] To KK-W, et al. COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing. Clin. Infect. Dis. 2020 doi: 10.1093/cid/ciaa1275. - DOI - PMC - PubMed

[10] To KK-W, et al. COVID-19 re-infection by a phylogenetically distinct SARS-coronavirus-2 strain confirmed by whole genome sequencing. Clin. Infect. Dis. 2020 doi: 10.1093/cid/ciaa1275. - DOI - PMC - PubMed

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Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months

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Changes in the humoral immunity response in SARS-CoV-2 convalescent patients over 8 months

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