Optogenetic Modulation of Ion Channels by Photoreceptive Proteins

doi:10.1007/978-981-15-8763-4_5

Review

. 2021:1293:73-88.

doi: 10.1007/978-981-15-8763-4_5.

Optogenetic Modulation of Ion Channels by Photoreceptive Proteins

Hisao Tsukamoto^{1

2

3}, Yuji Furutani^{4

5}

Affiliations

¹ Department of Life and Coordination-Complex Molecular Science, Institute for Molecular Science, Okazaki, Japan. tsukamoh@people.kobe-u.ac.jp.
² Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO), Kawaguchi, Japan. tsukamoh@people.kobe-u.ac.jp.
³ Department of Biology, Kobe University, Kobe, Japan. tsukamoh@people.kobe-u.ac.jp.
⁴ Department of Life and Coordination-Complex Molecular Science, Institute for Molecular Science, Okazaki, Japan.
⁵ Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan.

PMID: 33398808
DOI: 10.1007/978-981-15-8763-4_5

Review

Optogenetic Modulation of Ion Channels by Photoreceptive Proteins

Hisao Tsukamoto et al. Adv Exp Med Biol. 2021.

. 2021:1293:73-88.

doi: 10.1007/978-981-15-8763-4_5.

Authors

Hisao Tsukamoto^{1

2

3}, Yuji Furutani^{4

5}

Affiliations

¹ Department of Life and Coordination-Complex Molecular Science, Institute for Molecular Science, Okazaki, Japan. tsukamoh@people.kobe-u.ac.jp.
² Japan Science and Technology Agency (JST), Precursory Research for Embryonic Science and Technology (PRESTO), Kawaguchi, Japan. tsukamoh@people.kobe-u.ac.jp.
³ Department of Biology, Kobe University, Kobe, Japan. tsukamoh@people.kobe-u.ac.jp.
⁴ Department of Life and Coordination-Complex Molecular Science, Institute for Molecular Science, Okazaki, Japan.
⁵ Department of Life Science and Applied Chemistry, Nagoya Institute of Technology, Nagoya, Japan.

PMID: 33398808
DOI: 10.1007/978-981-15-8763-4_5

Abstract

In these 15 years, researches to control cellular responses by light have flourished dramatically to establish "optogenetics" as a research field. In particular, light-dependent excitation/inhibition of neural cells using channelrhodopsins or other microbial rhodopsins is the most powerful and the most widely used optogenetic technique. New channelrhodopsin-based optogenetic tools having favorable characteristics have been identified from a wide variety of organisms or created through mutagenesis. Despite the great efforts, some neuronal activities are still hard to be manipulated by the channelrhodopsin-based tools, indicating that complementary approaches are needed to make optogenetics more comprehensive. One of the feasible and complementary approaches is optical control of ion channels using photoreceptive proteins other than channelrhodopsins. In particular, animal opsins can modulate various ion channels via light-dependent G protein activation. In this chapter, we summarize how such alternative optogenetic tools work and they will be improved.

Keywords: G protein-coupled receptor; Ion channel; Membrane protein; Opsin; Optogenetics; Rhodopsin.

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References

1. Airan RD, Thompson KR, Fenno LE, Bernstein H, Deisseroth K (2009) Temporally precise in vivo control of intracellular signalling. Nature 458(7241):1025–1029
1. Arendt D, Tessmar-Raible K, Snyman H, Dorresteijn AW, Wittbrodt J (2004) Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain. Science 306(5697):869–871 - PubMed
1. Arosio D, Ratto GM (2014) Twenty years of fluorescence imaging of intracellular chloride. Front Cell Neurosci 8:258 - PubMed - PMC
1. Asano T, Igarashi H, Ishizuka T, Yawo H (2018) Organelle optogenetics: direct manipulation of intracellular Ca(2+) dynamics by light. Front Neurosci 12:561 - PubMed - PMC
1. Ashida A, Matsumoto K, Ebrey TG, Tsuda M (2004) A purified agonist-activated G-protein coupled receptor: truncated octopus acid Metarhodopsin. Zool Sci 21(3):245–250

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[1] Airan RD, Thompson KR, Fenno LE, Bernstein H, Deisseroth K (2009) Temporally precise in vivo control of intracellular signalling. Nature 458(7241):1025–1029

[2] Airan RD, Thompson KR, Fenno LE, Bernstein H, Deisseroth K (2009) Temporally precise in vivo control of intracellular signalling. Nature 458(7241):1025–1029

[3] Arendt D, Tessmar-Raible K, Snyman H, Dorresteijn AW, Wittbrodt J (2004) Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain. Science 306(5697):869–871 - PubMed

[4] Arendt D, Tessmar-Raible K, Snyman H, Dorresteijn AW, Wittbrodt J (2004) Ciliary photoreceptors with a vertebrate-type opsin in an invertebrate brain. Science 306(5697):869–871 - PubMed

[5] Arosio D, Ratto GM (2014) Twenty years of fluorescence imaging of intracellular chloride. Front Cell Neurosci 8:258 - PubMed - PMC

[6] Arosio D, Ratto GM (2014) Twenty years of fluorescence imaging of intracellular chloride. Front Cell Neurosci 8:258 - PubMed - PMC

[7] Asano T, Igarashi H, Ishizuka T, Yawo H (2018) Organelle optogenetics: direct manipulation of intracellular Ca(2+) dynamics by light. Front Neurosci 12:561 - PubMed - PMC

[8] Asano T, Igarashi H, Ishizuka T, Yawo H (2018) Organelle optogenetics: direct manipulation of intracellular Ca(2+) dynamics by light. Front Neurosci 12:561 - PubMed - PMC

[9] Ashida A, Matsumoto K, Ebrey TG, Tsuda M (2004) A purified agonist-activated G-protein coupled receptor: truncated octopus acid Metarhodopsin. Zool Sci 21(3):245–250

[10] Ashida A, Matsumoto K, Ebrey TG, Tsuda M (2004) A purified agonist-activated G-protein coupled receptor: truncated octopus acid Metarhodopsin. Zool Sci 21(3):245–250

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Optogenetic Modulation of Ion Channels by Photoreceptive Proteins

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Optogenetic Modulation of Ion Channels by Photoreceptive Proteins

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