Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec 24;22(1):107.
doi: 10.3390/ijms22010107.

Neuroprotective Effects of Coffee Bioactive Compounds: A Review

Katarzyna Socała  1 , Aleksandra Szopa  2 , Anna Serefko  2 , Ewa Poleszak  2 , Piotr Wlaź  1
Affiliations
Review

Neuroprotective Effects of Coffee Bioactive Compounds: A Review

Katarzyna Socała et al. Int J Mol Sci. .

Abstract

Coffee is one of the most widely consumed beverages worldwide. It is usually identified as a stimulant because of a high content of caffeine. However, caffeine is not the only coffee bioactive component. The coffee beverage is in fact a mixture of a number of bioactive compounds such as polyphenols, especially chlorogenic acids (in green beans) and caffeic acid (in roasted coffee beans), alkaloids (caffeine and trigonelline), and the diterpenes (cafestol and kahweol). Extensive research shows that coffee consumption appears to have beneficial effects on human health. Regular coffee intake may protect from many chronic disorders, including cardiovascular disease, type 2 diabetes, obesity, and some types of cancer. Importantly, coffee consumption seems to be also correlated with a decreased risk of developing some neurodegenerative conditions such as Alzheimer's disease, Parkinson's disease, and dementia. Regular coffee intake may also reduce the risk of stroke. The mechanism underlying these effects is, however, still poorly understood. This review summarizes the current knowledge on the neuroprotective potential of the main bioactive coffee components, i.e., caffeine, chlorogenic acid, caffeic acid, trigonelline, kahweol, and cafestol. Data from both in vitro and in vivo preclinical experiments, including their potential therapeutic applications, are reviewed and discussed. Epidemiological studies and clinical reports on this matter are also described. Moreover, potential molecular mechanism(s) by which coffee bioactive components may provide neuroprotection are reviewed.

Keywords: Alzheimer’s disease; Parkinson’s disease; caffeic acid; caffeine; chlorogenic acid; coffee consumption; neuroprotection; stroke; trigonelline.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Structures of the most important bioactive compounds in coffee. (A) structures of key compounds not belonging to chlorogenic acids, (B) general structure of chlorogenic acids and the most important groups found in chlorogenic acids from coffee beans, (C) structures of caffeoylquinic acids found in coffee beans.
Figure 2
Figure 2
Examples of the structure of coffee melanoidins [38,39].
Figure 3
Figure 3
Summary of the neuroprotective effects of coffee.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Clifford M.N., Gibson C.L., Rakotomalala J.-J.R., Cross E., Charrier A. Caffeine from green beans of Mascarocoffea. Phytochemistry. 1991;30:4039–4040. doi: 10.1016/0031-9422(91)83461-S. - DOI
    1. Cheek M., Csiba L., Bridson D.M. A new species of Coffea (Rubiaceae) from western Cameroon. Kew Bull. 2002;57:675–680. doi: 10.2307/4110998. - DOI
    1. Davis A.P., Rakotonasolo F. New species of Coffea L. (Rubiaceae) from Madagascar. Bot. J. Linn. Soc. 2003;142:111–118. doi: 10.1046/j.1095-8339.2003.00154.x. - DOI
    1. Davis A.P., Mvungi E.F. Two new and endangered species of Coffea (Rubiaceae) from the Eastern Arc Mountains (Tanzania) and notes on associated conservation issues. Bot. J. Linn. Soc. 2004;146:111–118. doi: 10.1111/j.1095-8339.2004.00328.x. - DOI
    1. Davis A.P., Govaerts R., Bridson D.M., Stoffelen P. An annotated taxonomic conspectus of the genus Coffea (Rubiaceae) Bot. J. Linn. Soc. 2006;152:465–512. doi: 10.1111/j.1095-8339.2006.00584.x. - DOI

MeSH terms