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Review
. 2020 Dec 10:8:585644.
doi: 10.3389/fcell.2020.585644. eCollection 2020.

Bone and Muscle Crosstalk in Aging

Chen He  1 , Wenzhen He  1 , Jing Hou  1 , Kaixuan Chen  1 , Mei Huang  1 , Mi Yang  1 , Xianghang Luo  1   2   3 , Changjun Li  1   2   3
Affiliations
Review

Bone and Muscle Crosstalk in Aging

Chen He et al. Front Cell Dev Biol. .

Abstract

Osteoporosis and sarcopenia are two age-related diseases that affect the quality of life in the elderly. Initially, they were thought to be two independent diseases; however, recently, increasing basic and clinical data suggest that skeletal muscle and bone are both spatially and metabolically connected. The term "osteosarcopenia" is used to define a condition of synergy of low bone mineral density with muscle atrophy and hypofunction. Bone and muscle cells secrete several factors, such as cytokines, myokines, and osteokines, into the circulation to influence the biological and pathological activities in local and distant organs and cells. Recent studies reveal that extracellular vesicles containing microRNAs derived from senescent skeletal muscle and bone cells can also be transported and aid in regulating bone-muscle crosstalk. In this review, we summarize the age-related changes in the secretome and extracellular vesicle-microRNAs secreted by the muscle and bone, and discuss their interactions between muscle and bone cells during aging.

Keywords: aging; bone; crosstalk; muscle; osteosarcopenia.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Myokines and osteokines altered with age in bone-muscle crosstalk. The plus symbol indicates positive association with bone/muscle mass; minus symbol indicates negative association with bone/muscle mass; upward and downward arrows indicate expression increase and decrease, respectively; question mark and the dotted line indicate that the function on bone/muscle is unclear.
FIGURE 2
FIGURE 2
Potentially different expression of senescent-EV-microRNAs in bone-muscle crosstalk. The plus symbol indicates positive association with bone/muscle mass; minus symbol indicates negative association with bone/muscle mass; upward arrow indicates expression increase; the dotted line indicates that the function on bone/muscle is unclear.
See this image and copyright information in PMC

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