Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery

doi:10.3390/molecules25235658

Editorial

. 2020 Dec 1;25(23):5658.

doi: 10.3390/molecules25235658.

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery

Mariana Spetea¹, Helmut Schmidhammer¹

Affiliations

Affiliation

¹ Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria.

PMID: 33271753
PMCID: PMC7730540
DOI: 10.3390/molecules25235658

Editorial

Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery

Mariana Spetea et al. Molecules. 2020.

. 2020 Dec 1;25(23):5658.

doi: 10.3390/molecules25235658.

Authors

Mariana Spetea¹, Helmut Schmidhammer¹

Affiliation

¹ Department of Pharmaceutical Chemistry, Institute of Pharmacy and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, 6020 Innsbruck, Austria.

PMID: 33271753
PMCID: PMC7730540
DOI: 10.3390/molecules25235658

Abstract

The interest in opioids such as morphine, the prototypical opioid ligand, has been maintained throughout the years [...].

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Sobczak Ł., Goryński K. Pharmacological Aspects of Over-the-Counter Opioid Drugs Misuse. Molecules. 2020;25:3905. doi: 10.3390/molecules25173905. - DOI - PMC - PubMed
1. Wang M., Irvin T.C., Herdman C.A., Hanna R.D., Hassan S.A., Lee Y.-S., Kaska S., Crowley R.S., Prisinzano T.E., Withey S.L., et al. The Intriguing Effects of Substituents in the N-Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of “Tail Wags Dog” Experiments. Molecules. 2020;25:2640. doi: 10.3390/molecules25112640. - DOI - PMC - PubMed
1. Kutsumura N., Koyama Y., Saitoh T., Yamamoto N., Nagumo Y., Miyata Y., Hokari R., Ishiyama A., Iwatsuki M., Otoguro K., et al. Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities. Molecules. 2020;25:1112. doi: 10.3390/molecules25051112. - DOI - PMC - PubMed
1. Iwamatsu C., Hayakawa D., Kono T., Honjo A., Ishizaki S., Hirayama S., Gouda H., Fujii H. Effects of N-Substituents on the Functional Activities of Naltrindole Derivatives for the δ Opioid Receptor: Synthesis and Evaluation of Sulfonamide Derivatives. Molecules. 2020;25:3792. doi: 10.3390/molecules25173792. - DOI - PMC - PubMed
1. Tymecka D., Lipiński P.F.J., Kosson P., Misicka A. β2-Homo-Amino Acid Scan of µ-Selective Opioid Tetrapeptide TAPP. Molecules. 2020;25:2461. doi: 10.3390/molecules25102461. - DOI - PMC - PubMed

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[1] Sobczak Ł., Goryński K. Pharmacological Aspects of Over-the-Counter Opioid Drugs Misuse. Molecules. 2020;25:3905. doi: 10.3390/molecules25173905. - DOI - PMC - PubMed

[2] Sobczak Ł., Goryński K. Pharmacological Aspects of Over-the-Counter Opioid Drugs Misuse. Molecules. 2020;25:3905. doi: 10.3390/molecules25173905. - DOI - PMC - PubMed

[3] Wang M., Irvin T.C., Herdman C.A., Hanna R.D., Hassan S.A., Lee Y.-S., Kaska S., Crowley R.S., Prisinzano T.E., Withey S.L., et al. The Intriguing Effects of Substituents in the N-Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of “Tail Wags Dog” Experiments. Molecules. 2020;25:2640. doi: 10.3390/molecules25112640. - DOI - PMC - PubMed

[4] Wang M., Irvin T.C., Herdman C.A., Hanna R.D., Hassan S.A., Lee Y.-S., Kaska S., Crowley R.S., Prisinzano T.E., Withey S.L., et al. The Intriguing Effects of Substituents in the N-Phenethyl Moiety of Norhydromorphone: A Bifunctional Opioid from a Set of “Tail Wags Dog” Experiments. Molecules. 2020;25:2640. doi: 10.3390/molecules25112640. - DOI - PMC - PubMed

[5] Kutsumura N., Koyama Y., Saitoh T., Yamamoto N., Nagumo Y., Miyata Y., Hokari R., Ishiyama A., Iwatsuki M., Otoguro K., et al. Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities. Molecules. 2020;25:1112. doi: 10.3390/molecules25051112. - DOI - PMC - PubMed

[6] Kutsumura N., Koyama Y., Saitoh T., Yamamoto N., Nagumo Y., Miyata Y., Hokari R., Ishiyama A., Iwatsuki M., Otoguro K., et al. Structure-Activity Relationship between Thiol Group-Trapping Ability of Morphinan Compounds with a Michael Acceptor and Anti-Plasmodium falciparum Activities. Molecules. 2020;25:1112. doi: 10.3390/molecules25051112. - DOI - PMC - PubMed

[7] Iwamatsu C., Hayakawa D., Kono T., Honjo A., Ishizaki S., Hirayama S., Gouda H., Fujii H. Effects of N-Substituents on the Functional Activities of Naltrindole Derivatives for the δ Opioid Receptor: Synthesis and Evaluation of Sulfonamide Derivatives. Molecules. 2020;25:3792. doi: 10.3390/molecules25173792. - DOI - PMC - PubMed

[8] Iwamatsu C., Hayakawa D., Kono T., Honjo A., Ishizaki S., Hirayama S., Gouda H., Fujii H. Effects of N-Substituents on the Functional Activities of Naltrindole Derivatives for the δ Opioid Receptor: Synthesis and Evaluation of Sulfonamide Derivatives. Molecules. 2020;25:3792. doi: 10.3390/molecules25173792. - DOI - PMC - PubMed

[9] Tymecka D., Lipiński P.F.J., Kosson P., Misicka A. β2-Homo-Amino Acid Scan of µ-Selective Opioid Tetrapeptide TAPP. Molecules. 2020;25:2461. doi: 10.3390/molecules25102461. - DOI - PMC - PubMed

[10] Tymecka D., Lipiński P.F.J., Kosson P., Misicka A. β2-Homo-Amino Acid Scan of µ-Selective Opioid Tetrapeptide TAPP. Molecules. 2020;25:2461. doi: 10.3390/molecules25102461. - DOI - PMC - PubMed

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Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery

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Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery

Authors

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Abstract

Conflict of interest statement

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Abstract

Conflict of interest statement

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