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Review
. 2021 Jan:142:104923.
doi: 10.1016/j.neuint.2020.104923. Epub 2020 Nov 25.

Brain injury and repair after intracerebral hemorrhage: The role of microglia and brain-infiltrating macrophages

Rajaneekar Dasari  1 , Frederick Bonsack  1 , Sangeetha Sukumari-Ramesh  2
Affiliations
Review

Brain injury and repair after intracerebral hemorrhage: The role of microglia and brain-infiltrating macrophages

Rajaneekar Dasari et al. Neurochem Int. 2021 Jan.

Abstract

Intracerebral hemorrhage (ICH) is a major public health problem characterized by cerebral bleeding. Despite recent advances in preclinical studies, there is no effective treatment for ICH making it the deadliest subtype of stroke. The lack of effective treatment options partly attributes to the complexity as well as poorly defined pathophysiology of ICH. The emerging evidence indicates the potential of targeting secondary brain damage and hematoma resolution for improving neurological outcomes after ICH. Herein, we provide an overview of our understanding of the functional roles of activated microglia and brain-infiltrating monocyte-derived macrophages in brain injury and repair after ICH. The clinical and preclinical aspects that we discuss in this manuscript are related to ICH that occurs in adults, but not in infants. Also, we attempt to identify the knowledge gap in the field for future functional studies given the potential of targeting microglia and brain-infiltrating macrophages for therapeutic intervention after ICH.

Keywords: Brain injury; Intracerebral hemorrhage; Macrophages; Microglia; Repair.

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Conflict of interest statement

Declarations of interest

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References

    1. An SJ, Kim TJ, and Yoon BW, Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update. J Stroke, 2017. 19(1): p. 3–10. - PMC - PubMed
    1. Qureshi AI, Mendelow AD, and Hanley DF, Intracerebral haemorrhage. Lancet, 2009. 373(9675): p. 1632–44. - PMC - PubMed
    1. van Asch CJ, et al., Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis. Lancet Neurol, 2010. 9(2): p. 167–76. - PubMed
    1. Bonsack F.t., Alleyne CH Jr., and Sukumari-Ramesh S, Augmented expression of TSPO after intracerebral hemorrhage: a role in inflammation? J Neuroinflammation, 2016. 13(1): p. 151. - PMC - PubMed
    1. Aguilar MI and Freeman WD, Spontaneous intracerebral hemorrhage. Semin Neurol, 2010. 30(5): p. 555–64. - PubMed

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