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. 1987 Nov;7(11):4003-9.
doi: 10.1128/mcb.7.11.4003-4009.1987.

Functional expression of a heterologous major histocompatibility complex class I gene in transgenic mice

C Bieberich  1 , T Yoshioka, K Tanaka, G Jay, G Scangos
Affiliations

Functional expression of a heterologous major histocompatibility complex class I gene in transgenic mice

C Bieberich et al. Mol Cell Biol. 1987 Nov.

Abstract

The regulated expression of major histocompatibility complex class I antigens is essential for assuring proper cellular immune responses. To study H-2 class I gene regulation, we have transferred a foreign class I gene to inbred mice and have previously shown that the heterologous class I gene was expressed in a tissue-dependent manner. In this report, we demonstrate that these mice expressed the transgenic class I molecule on the cell surface without any alteration in the level of endogenous H-2 class I antigens. Skin grafts from transgenic mice were rapidly rejected by mice of the background strain, indicating that the transgenic antigen was expressed in an immunologically functional form. As with endogenous H-2 class I genes, the class I transgene was inducible by interferon treatment and suppressible by human adenovirus 12 transformation. Linkage analysis indicated that the transgene was not closely linked to endogenous class I loci, suggesting that trans-regulation of class I genes can occur for class I genes located outside the major histocompatibility complex.

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