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Case Reports
. 2020 Oct 11;12(10):e10898.
doi: 10.7759/cureus.10898.

Severe Acute Respiratory Syndrome Coronavirus 2 Induced Focal Segmental Glomerulosclerosis

Is-Haq O Malik  1 , Nida Ladiwala  1 , Siddharth Chinta  1 , Muhammad Khan  1 , Komal Patel  1
Affiliations
Case Reports

Severe Acute Respiratory Syndrome Coronavirus 2 Induced Focal Segmental Glomerulosclerosis

Is-Haq O Malik et al. Cureus. .

Abstract

Focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome affecting adults and children. Collapsing focal segmental glomerulosclerosis (FSGS), one of five histologic variants of FSGS is described as segmental or global collapse and sclerosis of the glomerular tufts and has been frequently associated with human immunodeficiency virus-associated nephropathy (HIVAN). Its association with other viral and non-viral causes, medications and other disease states has since been established. Due to its resistance to therapy, rapid progression to end-stage renal disease (ESRD) and overall poorer prognosis, identification with electron microscopy examination of the kidney biopsy sample is required during evaluation.

Keywords: acute kidney injury; apol1 gene; collapsing fsgs; covid-19; esrd; focal segmental glomerulosclerosis; fsgs; proteinuria; sars-cov-2; severe acute respiratory syndrome coronavirus 2.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Chest x-ray on admission
Figure 2
Figure 2. Renal Ultrasound
Figure 3
Figure 3. Renal Ultrasound - Right kidney
Figure 4
Figure 4. Renal Ultrasound - Left kidney
Figure 5
Figure 5. Collapsing Focal segmental glomerulosclerosis
Figure 6
Figure 6. Focal segmental glomerulosclerosis
Figure 7
Figure 7. Focal segmental glomerulosclerosis
Figure 8
Figure 8. Acute Tubular Injury
Figure 9
Figure 9. Tubular Microcyst
See this image and copyright information in PMC

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References

    1. Kidney disease is associated with in-hospital death of patients with COVID-19. Cheng Y, Luo R, Wang K, et al. Kidney Int. 2020;97:829–838. - PMC - PubMed
    1. Association of histologic variants in FSGS clinical trial with presenting features and outcomes. D’Agati VD, Alster JM, Jennette JC, et al. Clin J Am Soc Nephrol. 2013;8:399–406. - PMC - PubMed
    1. Human kidney is a target for novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Diao B, Feng Z, Wang C, et al. medRxiv. 2020 - PMC - PubMed
    1. Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China. Su H, Yang M, Wan C, et al. Kidney Int. 2020;98:219–227. - PMC - PubMed
    1. AKI in hospitalized patients with and without COVID- 19: a comparison study. Fisher M, Neugarten J, Bellin E, et al. J Am Soc Nephrol. 2020;31:2145–2157. - PMC - PubMed

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