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. 2020 Nov 10;6(4):276.
doi: 10.3390/jof6040276.

Candidemia in Children with Malignancies: Report from the Infection Working Group of the Hellenic Society of Pediatric Hematology-Oncology

Eleni Vasileiou  1 , Anna Paisiou  2 , Charoula Tsipou  3 , Apostolos Pourtsidis  4 , Vasiliki Galani  5 , Nikolaos Katzilakis  6 , Kondilia Antoniadi  7 , Eugenia Papakonstantinou  8 , Elda Ioannidou  2 , Efthichia Stiakaki  6 , Margarita Baka  4 , Antonios Kattamis  3 , Vasiliki Kitra  2 , Athanasios Tragiannidis  1
Affiliations

Candidemia in Children with Malignancies: Report from the Infection Working Group of the Hellenic Society of Pediatric Hematology-Oncology

Eleni Vasileiou et al. J Fungi (Basel). .

Abstract

Candidemia is an important cause of morbidity and mortality especially in immunocompromised and hospitalized patients. We retrospectively collected data of candidemia cases that occurred in the seven Hematology-Oncology Departments/Units of Greece and the Stem Cell Transplant Unit between 2015 and 2019. In total, 19 episodes of candidemia in 19 patients were recorded. The majority of the patients (78.9%) had at least one risk factor for candidemia. The most frequent risk factors associated with candidemia observed in our patients were prolonged duration of hospitalization (30 days, range 1-141), presence of a central venous catheter at diagnosis of candidemia (73.7%) and antibiotics use during the last two weeks (84.2%). Candida parapsilosis was the most common species isolated accounting for 42.1%, followed by C. albicans (26.3%) and C. famata (15.8%). Nearly all of the patients (84.2%) received antifungal monotherapy with liposomal amphotericin B or echinocandins. The central venous catheter was removed in 78.6% of patients and the median time between the first positive blood culture and catheter removal was 3 days (range 1-9). Mortality at 28 days was 26.3%. In conclusion, a predominance of non-albicans species was observed in our study in conformity with the global trend.

Keywords: C. parapsilosis; candida; candidemia; epidemiology; hematology; oncology; pediatric; risk factors; treatment.

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Conflict of interest statement

The authors declare no conflict of interest.

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