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Review
. 2020 Nov 1:26:e928996.
doi: 10.12659/MSM.928996.

Long-Term Respiratory and Neurological Sequelae of COVID-19

Fuzhou Wang  1 , Richard M Kream  2 , George B Stefano  2   3
Affiliations
Review

Long-Term Respiratory and Neurological Sequelae of COVID-19

Fuzhou Wang et al. Med Sci Monit. .

Abstract

Since the initial reports of coronavirus disease 2019 (COVID-19) in China in late 2019, infections from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have spread rapidly, resulting in a global pandemic that has caused millions of deaths. Initially, the large number of infected people required the direction of global healthcare resources to provide supportive care for the acutely ill population in an attempt to reduce mortality. While clinical trials for safe and effective antiviral agents are ongoing, and vaccine development programs are being accelerated, long-term sequelae of SARS-CoV-2 infection have become increasingly recognized and concerning. Although the upper and lower respiratory tracts are the main sites of entry of SARS-CoV-2 into the body, resulting in COVID-19 pneumonia as the most common presentation, acute lung damage may be followed by pulmonary fibrosis and chronic impairment of lung function, with impaired quality of life. Also, increasing reports have shown that SARS-CoV-2 infection involves the central nervous system (CNS) and the peripheral nervous system (PNS) and directly or indirectly damages neurons, leading to long-term neurological sequelae. This review aims to provide an update on the mechanisms involved in the development of the long-term sequelae of SARS-CoV-2 infection in the 3 main areas of lung injury, neuronal injury, and neurodegenerative diseases, including Alzheimer disease, Parkinson disease, and multiple sclerosis, and highlights the need for patient monitoring following the acute stage of infection with SARS-CoV-2 to provide a rationale for the prevention, diagnosis, and management of these potential long-term sequelae.

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Conflict of interest statement

Conflict of interest

None.

Figures

Figure 1
Figure 1
Respiratory injury associated with SARS-CoV-2 infection. SARS-CoV-2 induces inflammatory changes in all 3 main locations of the respiratory system from the trachea (A), to the bronchi (B), and the alveolar sacs (C). The respiratory system will experience acute inflammation following the pro-inflammatory ‘cytokine storm,’ followed by long-term fibrotic changes. Pulmonary fibrosis is associated with the upregulation of transforming growth factor-beta (TGF-β) and chronic inflammation.
Figure 2
Figure 2
Neuronal injury associated with SARS-CoV-2 infection. SARS-CoV-2 enters into the central nervous system (CNS) through 2 major routes: the olfactory pathway (#1 in A), and the blood–brain barrier (BBB) pathway (#2 in A). The virus can migrate into the CNS directly by endocytosis with the assistance of inflammatory cytokine-induced increased vascular permeability and indirect transfer via a ‘Trojan horse’ mechanism. (B) After binding to its membrane receptor, ACE2, SARS-CoV-2 will be engulfed into neuronal cytosol and move to connect with cytosol-located angiotensin-converting enzyme 2 (ACE2). The viral RNAs enter the mitochondria or form into autophagolysosomes to initiate autophagy and/or apoptosis. Microglia and immune cells produce pro-inflammatory cytokines, which result in further abnormalities in mitochondrial function. When the virus enters the neurons, it combines with the axonal microtubules with anterograde and retrograde spread to the synapse and enters the next level of neurons by trans-synaptic transfer and endocytosis. Both the virus and the ‘cytokine storm’ can destroy the myelin sheath of neurons, resulting in acute and chronic neuropathology.
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References

    1. Kannan S, Shaik Syed Ali P, Sheeza A, Hemalatha K. COVID-19 (Novel Coronavirus 2019) – recent trends. Eur Rev Med Pharmacol Sci. 2020;24(4):2006–11. - PubMed
    1. Wang F, Kream RM, Stefano GB. An evidence-based perspective on mRNA-SARS-CoV-2 vaccine development. Med Sci Monitm. 2020;26:e924700. - PMC - PubMed
    1. Oldfield E, Malwal SR. COVID-19 and other pandemics: How might they be prevented? ACS Infect Dis. 2020;6(7):1563–66. - PubMed
    1. Bourgonje AR, Abdulle AE, Timens W, et al. Angiotensin-converting enzyme 2 (ACE2), SARS-CoV-2 and the pathophysiology of coronavirus disease 2019 (COVID-19) J Pathol. 2020;251(3):228–48. - PMC - PubMed
    1. Helms J, Tacquard C, Severac F, et al. CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sepsis) High risk of thrombosis in patients with severe SARS-CoV-2 infection: A multicenter prospective cohort study. Intensive Care Med. 2020;46(6):1089–98. - PMC - PubMed

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