Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1987 May:386:439-54.
doi: 10.1113/jphysiol.1987.sp016543.

Beta-adrenergic blockade restores glucose's antiketogenic activity after exercise in carbohydrate-depleted athletes

J H Adams  1 , G Irving, J H Koeslag, J D Lochner, R C Sandell, C Wilkinson
Affiliations

Beta-adrenergic blockade restores glucose's antiketogenic activity after exercise in carbohydrate-depleted athletes

J H Adams et al. J Physiol. 1987 May.

Abstract

1. The development of post-exercise ketosis is not abolished by the ingestion of glucose immediately after exercise, despite inducing high insulin/glucagon ratios in the peripheral (and therefore by implication in the portal) blood. 2. To investigate the possibility of autonomic control of the liver influencing its sensitivity to the major counter-regulatory hormones, we administered 50 g glucose, either on its own, or together with 0.5 mg prazosine, 40 mg propranolol, or 15 mg propantheline, to forty-seven 48 h carbohydrate-starved athletes who had just run 25 km. 3. The blood 3-hydroxybutyrate concentration rose from 0.30 +/- 0.05 (mean +/- S.E. of mean) to 0.52 +/- 0.08 mmol/l with exercise, and then to 1.32 +/- 0.40 mmol/l at 6 h after exercise in subjects who had ingested only glucose after exercise. 4. The effects of prazosine and propantheline on the blood ketone body concentration at 2 h after exercise was not statistically significant. Propranolol, on the other hand, significantly lowered the blood 3-hydroxybutyrate concentration (compared with controls) to 0.09 +/- 0.03 mmol/l at 3 h (P less than 0.01), and 0.35 +/- 0.08 mmol/l at 6 h (P less than 0.01) after exercise. 5. The plasma insulin, glucagon, glucose and free fatty acid concentrations were unaffected by propranolol, indicating that the antiketogenesis was the result of a direct effect on ketone body metabolism. 6. Since beta-adrenergic blockade has not previously been shown to have antiketogenic activity, except in somatostatin-induced hyperketonaemia, it is concluded that its effectiveness in post-exercise ketosis can probably be ascribed to a functional hepatic insulin and glucagon deficiency.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Endocrinology. 1972 Sep;91(3):680-90 - PubMed
    1. Biochim Biophys Acta. 1982 Aug 6;717(2):385-6 - PubMed
    1. Am J Physiol. 1978 Mar;234(3):E252-6 - PubMed
    1. Am J Physiol. 1978 Sep;235(3):E255-60 - PubMed
    1. Diabetologia. 1978 Dec;15(6):433-9 - PubMed

Publication types

LinkOut - more resources