The combination of ginger powder and zinc supplement improves the fructose-induced metabolic syndrome in rats by modulating the hepatic expression of NF-κB, mTORC1, PPAR-α SREBP-1c, and Nrf2
- PMID: 33145794
- DOI: 10.1111/jfbc.13546
The combination of ginger powder and zinc supplement improves the fructose-induced metabolic syndrome in rats by modulating the hepatic expression of NF-κB, mTORC1, PPAR-α SREBP-1c, and Nrf2
Abstract
Although studies have shown that ginger, as an herbal remedy and zinc are able to improve inflammation, oxidative stress, autophagy, and metabolism of lipid and glucose, their molecular mechanisms are unknown. Therefore, this study was aimed to examine the therapeutic effects of ginger with zinc supplement for eight weeks on fructose-induced metabolic syndrome (MS). Ninety-six adult male Sprague Dawley rats (220 g ± 20) were randomly assigned to twelve controlled and treated groups. After the last treatment session, the level of lipid profiles, glucose, insulin, and leptin as metabolic factors and liver enzymes as biomarkers to evaluate liver function in serum were measured. The level of antioxidant enzymes and lipid peroxidation to evaluate the oxidative status and the TNF-α level as a biomarker to assess the state of inflammation in liver were also measured. The level of zinc along with the expression of NF-κB, mTORC1, PPAR-α, SREBP-1c, and Nrf2 in liver was also evaluated. The level of metabolic factors and liver enzymes in serum along with lipid peroxidation and TNF-α in liver increased; zinc and antioxidant enzymes levels decreased in rats with MS compared to control rats (p < .05). The hepatic expression of SREBP-1c, NF-κB and mTORC1 were upregulated and the expression of PPAR-α and Nrf2 were downregulated in rats with MS compared to control rats (p < .05). Treatment with different doses of ginger, zinc, and the combination of them could improve metabolic, inflammatory oxidative stress factors, and expression of the above genes in rats with MS compared to the MS group (p < .05). It can be concluded that ginger, zinc, and the combination of them could improve oxidative damage, inflammation, and autophagy induced by fructose and could adjust the glucose and lipid metabolism and the homeostasis of zinc in rats with MS. PRACTICAL APPLICATIONS: Due to the increasing prevalence of metabolic diseases, the use of plant compounds such as ginger has attracted widespread attention. Ginger as an herbal remedy with predominant pharmacological properties due to its availability, cheapness, and lack of side effects is also very popular for the treatment of metabolic disorders in folk medicine. Moreover, enhancing its medicinal properties with supplements such as zinc can be widely welcomed. This study was actually performed with the aim of investigating the effects of ginger + zinc supplement on MS. The results showed that the ginger + zinc supplement could improve oxidative damage, inflammation, and autophagy caused by fructose and adjust the glucose and lipid metabolism and the homeostasis of zinc in rats with MS. The results of this study support the hypothesis that ginger can be used as a very suitable option for the production of medicinal supplements to maintain human health.
Keywords: autophagy; ginger; inflammation; metabolic syndrome; oxidative stress; zinc.
© 2020 Wiley Periodicals LLC.
Similar articles
-
Safflower seed oil improves steroidogenesis and spermatogenesis in rats with type II diabetes mellitus by modulating the genes expression involved in steroidogenesis, inflammation and oxidative stress.J Ethnopharmacol. 2021 Jul 15;275:114139. doi: 10.1016/j.jep.2021.114139. Epub 2021 Apr 22. J Ethnopharmacol. 2021. PMID: 33894286
-
Cinnamon could improve hepatic steatosis caused by a high-fat diet via enhancing hepatic beta-oxidation and inhibiting hepatic lipogenesis, oxidative damage, and inflammation in male rats.J Food Biochem. 2022 Jun;46(6):e14077. doi: 10.1111/jfbc.14077. Epub 2022 Mar 4. J Food Biochem. 2022. PMID: 35246859
-
Magnesium isoglycyrrhizinate blocks fructose-induced hepatic NF-κB/NLRP3 inflammasome activation and lipid metabolism disorder.Eur J Pharmacol. 2017 Aug 15;809:141-150. doi: 10.1016/j.ejphar.2017.05.032. Epub 2017 May 17. Eur J Pharmacol. 2017. PMID: 28526339
-
Nutritional implications of ginger: chemistry, biological activities and signaling pathways.J Nutr Biochem. 2020 Dec;86:108486. doi: 10.1016/j.jnutbio.2020.108486. Epub 2020 Aug 19. J Nutr Biochem. 2020. PMID: 32827666 Review.
-
Ginger and its constituents: Role in treatment of inflammatory bowel disease.Biofactors. 2022 Jan;48(1):7-21. doi: 10.1002/biof.1808. Epub 2021 Dec 9. Biofactors. 2022. PMID: 34882874 Review.
Cited by
-
Ginger Extract and Omega-3 Fatty Acids Supplementation: A Promising Strategy to Improve Diabetic Cardiomyopathy.Physiol Res. 2024 Jul 17;73(3):351-367. doi: 10.33549/physiolres.935266. Physiol Res. 2024. PMID: 39027953 Free PMC article.
-
Ginger (Zingiber Officinale Roscoe) ameliorates ethanol-induced cognitive impairment by modulating NMDA and GABA-A receptors in rat hippocampus.Metab Brain Dis. 2024 Jan;39(1):67-76. doi: 10.1007/s11011-023-01301-8. Epub 2023 Nov 15. Metab Brain Dis. 2024. PMID: 37966694
-
Evaluation of Expression of Cytochrome P450 Aromatase and Inflammatory, Oxidative, and Apoptotic Markers in Testicular Tissue of Obese Rats (Pre)Treated with Garlic Powder.Evid Based Complement Alternat Med. 2023 Jan 4;2023:4858274. doi: 10.1155/2023/4858274. eCollection 2023. Evid Based Complement Alternat Med. 2023. PMID: 36644444 Free PMC article.
-
Pre-germinated brown rice alleviates non-alcoholic fatty liver disease induced by high fructose and high fat intake in rat.J Clin Biochem Nutr. 2022 May;70(3):248-255. doi: 10.3164/jcbn.21-158. Epub 2022 Mar 24. J Clin Biochem Nutr. 2022. PMID: 35692676 Free PMC article.
-
Association Between Dietary Zinc Intake and Metabolic Syndrome. A Meta-Analysis of Observational Studies.Front Nutr. 2022 Feb 3;9:825913. doi: 10.3389/fnut.2022.825913. eCollection 2022. Front Nutr. 2022. PMID: 35187040 Free PMC article.
References
REFERENCES
-
- Aebi, H. (1984). [13] Catalase in vitro. Methods in Enzymology, 105, 121-126.
-
- Akbari, A., Nasiri, K., & Heydari, M. (2020). Ginger (Zingiber officinale Roscoe) extract can improve the levels of some trace elements and total homocysteine and prevent oxidative damage induced by ethanol in rat eye. Avicenna Journal of Phytomedicine, 10(4), 365-371.
-
- Akbari, A., Nasiri, K., Heydari, M., Mosavat, S. H., & Iraji, A. (2017). The protective effect of hydroalcoholic extract of Zingiber officinale Roscoe (Ginger) on ethanol-induced reproductive toxicity in male rats. Journal of evidence-based Complementary & Alternative Medicine, 22(4), 609-617.
-
- Akbari, A., Nasiri, K., Heydari, M., Nimrouzi, M., & Afsar, T. (2019). Ameliorating potential of ginger (Zingiber officinale Roscoe) extract on liver function and oxidative stress induced by ethanol in male rats. Zahedan Journal of Research in Medical Sciences, e86464.
-
- Baena, M., Sanguesa, G., Hutter, N., Sánchez, R. M., Roglans, N., Laguna, J. C., & Alegret, M. (2015). Fructose supplementation impairs rat liver autophagy through mTORC activation without inducing endoplasmic reticulum stress. Biochimica Et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 1851(2), 107-116. https://doi.org/10.1016/j.bbalip.2014.11.003
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical