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Review
. 2021 Jun;64(6):957-965.
doi: 10.1007/s11427-020-1796-0. Epub 2020 Oct 30.

Ubiquitination modification: critical regulation of IRF family stability and activity

Bao-Qin Liu  1   2 , Jin Jin  2   3 , Yi-Yuan Li  4   5
Affiliations
Review

Ubiquitination modification: critical regulation of IRF family stability and activity

Bao-Qin Liu et al. Sci China Life Sci. 2021 Jun.

Abstract

Interferon regulatory factors (IRFs) play pivotal and critical roles in innate and adaptive immune responses; thus, precise and stringent regulation of the stability and activation of IRFs in physiological processes is necessary. The stability and activities of IRFs are directly or indirectly targeted by endogenous and exogenous proteins in an ubiquitin-dependent manner. However, few reviews have summarized how host E3 ligases/DUBs or viral proteins regulate IRF stability and activity. Additionally, with recent technological developments, details about the ubiquitination of IRFs have been continuously revealed. As knowledge of how these proteins function and interact with IRFs may facilitate a better understanding of the regulation of IRFs in immune responses or other biological processes, we summarized current studies on the direct ubiquitination of IRFs, with an emphasis on how these proteins interact with IRFs and affect their activities, which may provide exciting targets for drug development by regulating the functions of specific E3 ligases.

Keywords: E3 ubiquitin ligase; IRFs; activation; degradation; ubiquitination; viral proteins.

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References

    1. Arnold MM. The rotavirus interferon antagonist NSP1: Many targets, many questions. J Virol. 2016;90:5212–5215. - PMC - PubMed
    1. Balkhi MY, Fitzgerald KA, Pitha PM. Functional regulation of MyD88-activated interferon regulatory factor 5 by K63-linked polyubiquitination. Mol Cell Biol. 2008;28:7296–7308. - PMC - PubMed
    1. Barro M, Patton JT. Rotavirus nonstructural protein 1 subverts innate immune response by inducing degradation of IFN regulatory factor 3. Proc Natl Acad Sci USA. 2005;102:4114–4119. - PMC - PubMed
    1. Barro M, Patton JT. Rotavirus NSP1 inhibits expression of type I interferon by antagonizing the function of interferon regulatory factors IRF3, IRF5, and IRF7. J Virol. 2007;81:4473–4481. - PMC - PubMed
    1. Bauhofer O, Summerfield A, Sakoda Y, Tratschin JD, Hofmann M A, Ruggli N. Classical swine fever virus Npro interacts with interferon regulatory factor 3 and induces its proteasomal degradation. J Virol. 2007;81:3087–3096. - PMC - PubMed