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Review
. 2020 Dec;34(4):921-943.
doi: 10.1016/j.idc.2020.05.003.

Emerging Issues in Antifungal Resistance

John R Perfect  1 , Mahmoud Ghannoum  2
Affiliations
Review

Emerging Issues in Antifungal Resistance

John R Perfect et al. Infect Dis Clin North Am. 2020 Dec.

Abstract

Invasive fungal diseases continue to cause substantial mortality in the enlarging immunocompromised population. It is fortunate that the field has moved past amphotericin B deoxycholate as the only available antifungal drug but despite new classes of antifungal agents both primary and secondary drug resistance in molds and yeasts abound. From the rise of multiple-drug-resistant Candida auris to the agrochemical selection of environmental azole-resistant Aspergillus fumigatus, it is and will be critical to understand antifungal drug resistance and both prevent and treat it with new strategies and agents.

Keywords: Antifungal agents; Drug resistance; Fungi; Invasive fungal disease.

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