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. 2020 Sep 1;13(9):2312-2318.
eCollection 2020.

Kank1 and Ki67 expression are associated with poor prognosis in human pulmonary adenocarcinoma

Xiao-Chun Shen  1 , Chong-Jun Ni  1 , Song-Tao Xu  2   3 , Sheng-Hua Zhan  4 , Guo-Jian Gu  5   6
Affiliations

Kank1 and Ki67 expression are associated with poor prognosis in human pulmonary adenocarcinoma

Xiao-Chun Shen et al. Int J Clin Exp Pathol. .

Abstract

KN motif and ankyrin repeat domains 1 (Kank1) and ki67 are associated with tumorigenesis and progression. This paper researched the expression of Kank1 and Ki67 and their clinicopathologic significance in pulmonary adenocarcinoma (PA). We monitored the expression of KanK1 and ki67 in 94 cases of human PA and 31 cases of paracancerous tissue by the immunohistochemical method. The results showed that Kank1 protein was detected in 74.2% (41/94) of PA tissues, and they were associated with differentiation (P = 0.025) and lymphatic metastasis (P = 0.002). Kaplan-Meier analysis suggested that patients with low Kank1 expression had shorter overall survival in PA (P = 0.020). Ki67 protein was detected in 79.8% (75/94) of PA tissues, and they were associated with differentiation (P < 0.001), TNM classification (P = 0.007), and lymphatic metastasis (P = 0.044). Furthermore, Kaplan-Meier analysis showed that patients with overexpression of Ki67 had shorter overall survival (P = 0.014). Cox multivariate analysis showed that tumor differentiation, TNM classification, lymphatic metastasis, Kank1, and ki67 expression were independent factors for prognosis of PA (P = 0.012, 0.016, 0.007, 0.021 and P = 0.003 respectively). In conclusion, compared with paracancerous tissues, Kank1 had low expression, while Ki67 was overexpressed in PA. They are closely related to its occurrence and development, and the prognosis of patients with low expression of Kank1 or overexpression of ki67 was poor in PA. Kank1 and Ki67 can be helpful for diagnosing and detecting the prognosis of patients with PA.

Keywords: Kank1; immunohistochemistry; ki67; prognosis; pulmonary adenocarcinoma.

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Conflict of interest statement

None.

Figures

Figure 1
Figure 1
Kank1 had positive expression in pulmonary adenocarcinoma tissues manifested by brown granules in the cytoplasm (200×) (A). Kank1 was not expressed in pulmonary adenocarcinoma tissues and the cells were not stained (200×) (B). Ki67 had positive expression in pulmonary adenocarcinoma tissues and there were brown granules in the nuclei (200×) (C). Ki67 was not expressed in PA (200×) (D).
Figure 2
Figure 2
Kaplan-Meier survival curves of pulmonary adenocarcinoma patients according to Kank1 expression (A) or Ki67 expression (B).
See this image and copyright information in PMC

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