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. 2020 Sep 16:2020:4875764.
doi: 10.1155/2020/4875764. eCollection 2020.

An Overview of the Mechanism of Penthorum chinense Pursh on Alcoholic Fatty Liver

Xingtao Zhao  1   2   3 , Liao Li  1   2   3 , Mengting Zhou  1   2   3 , Meichen Liu  1   2   3 , Ying Deng  1   2   3 , Linfeng He  1   2   3 , Chaocheng Guo  1   2   3 , Yunxia Li  1   2   3
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An Overview of the Mechanism of Penthorum chinense Pursh on Alcoholic Fatty Liver

Xingtao Zhao et al. Evid Based Complement Alternat Med. .

Abstract

Alcohol liver disease (ALD) caused by excessive alcohol consumption is a progressive disease, and alcohol fatty liver disease is the primary stage. Currently, there is no approved drug for its treatment. Abstinence is the best way to heal, but patients' compliance is poor. Unlike other chronic diseases, alcohol fatty liver disease is not caused by nutritional deficiencies; it is caused by the molecular action of ingested alcohol and its metabolites. More and more studies have shown the potential of Penthorum chinense Pursh (PCP) in the clinical use of alcohol fatty liver treatment. The purpose of this paper is to reveal from the essence of PCP treatment of alcohol liver mechanism mainly by the ethanol dehydrogenase (ADH) and microsomal ethanol oxidation system-dependent cytochrome P4502E1 (CYP2E1) to exert antilipogenesis, antioxidant, anti-inflammatory, antiapoptotic, and autophagy effects, with special emphasis on its mechanisms related to SIRT1/AMPK, KEAP-1/Nrf2, and TLR4/NF-κB. Overall, data from the literature shows that PCP appears to be a promising hepatoprotective traditional Chinese medicine (TCM).

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Conflict of interest statement

The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Diagram of the mechanism of PCP on alcohol liver disease.
See this image and copyright information in PMC

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References

    1. Browning J. D., Horton J. D. Molecular mediators of hepatic steatosis and liver injury. Journal of Clinical Investigation. 2004;114(2):147–152. doi: 10.1172/jci200422422. - DOI - PMC - PubMed
    1. Williams R., Alexander G., Aspinall R., et al. Gathering momentum for the way ahead: fifth report of the lancet standing commission on liver disease in the UK. The Lancet. 2018;392(10162):2398–2412. doi: 10.1016/s0140-6736(18)32561-3. - DOI - PubMed
    1. Singal A. K., Bataller R., Ahn J., Kamath P. S., Shah V. H. ACG clinical guideline: alcoholic liver disease. American Journal of Gastroenterology. 2018;113(2):175–194. doi: 10.1038/ajg.2017.469. - DOI - PMC - PubMed
    1. Stickel F., Datz C., Hampe J., Bataller R. Pathophysiology and management of alcoholic liver disease: update 2016. Gut and Liver. 2017;11(2):173–188. doi: 10.5009/gnl16477. - DOI - PMC - PubMed
    1. Gala K. S., Vatsalya V. Emerging noninvasive biomarkers, and medical management strategies for alcoholic hepatitis: present understanding and scope. Cells. 2020;9(3):p. 524. doi: 10.3390/cells9030524. - DOI - PMC - PubMed

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