Review
doi: 10.1016/0014-5793(87)80664-6.
Structural features in aminoacyl-tRNAs required for recognition by elongation factor Tu
- PMID: 3297780
- DOI: 10.1016/0014-5793(87)80664-6
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Review
Structural features in aminoacyl-tRNAs required for recognition by elongation factor Tu
FEBS Lett.
.
Free article
Abstract
In bacterial polypeptide synthesis aminoacyl-tRNA (aa-tRNA) bound to elongation factor Tu (EF-Tu) and GTP is part of a crucial intermediate ribonucleoprotein complex involved in the decoding of messenger RNA. The conformation and topology as well as the affinity of the macromolecules in this ternary aa-tRNA X EF-Tu X GTP complex are of fundamental importance for the nature of the interaction of the complex with the ribosome. The structural elements of aa-tRNA required for interaction with EF-Tu and GTP and the resulting functional implications are presented here.
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