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Review
. 2020 Sep 1:7:2049936120941725.
doi: 10.1177/2049936120941725. eCollection 2020 Jan-Dec.

Vector-borne diseases in pregnancy

Brendan O'Kelly  1 , John S Lambert  2
Affiliations
Review

Vector-borne diseases in pregnancy

Brendan O'Kelly et al. Ther Adv Infect Dis. .

Abstract

Vector-borne infections cause a significant proportion of world-wide morbidity and mortality and many are increasing in incidence. This is due to a combination of factors, primarily environmental change, encroachment of human habitats from urban to peri-urban areas and rural to previously uninhabited areas, persistence of poverty, malnutrition and resource limitation in geographical areas where these diseases are endemic. Pregnant women represent the single largest 'at risk' group, due to immune-modulation and a unique physiological state. Many of these diseases have not benefitted from the same level of drug development as other infectious and medical domains, a factor attributing to the 'neglected tropical disease' title many vector-borne diseases hold. Pregnancy compounds this issue as data for safety and efficacy for many drugs is practically non-existent, precluding exposure in pregnancy to many first-line therapeutic agents for 'fear of the unknown' or overstated adverse pregnancy-foetal outcomes. In this review, major vector-borne diseases, their impact on pregnancy outcomes, current treatment, vaccination and short-comings of current medical practice for pregnant women will be discussed.

Keywords: neglected tropical diseases; pregnancy; vector-borne diseases.

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Conflict of interest statement

Conflict of interest statement: The authors declare that there is no conflict of interest.

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References

    1. World Health Organization. A global brief on vector-borne diseases, https://apps.who.int/iris/bitstream/handle/10665/111008/WHO_DCO_WHD_2014... (2014). (accessed 12 June 2020).
    1. World Health Organization. Global vector control response 2017–2030. Geneva: World Health Organization, 2014.
    1. Franklinos LHV, Jones KE, Redding DW, et al. The effect of global change on mosquito-borne disease. Lancet Infect Dis 2019; 19: e302–e312. - PubMed
    1. Mead PS. Epidemiology of Lyme disease. Infect Dis Clin North Am 2015; 29: 187–210. - PubMed
    1. Vandekerckhove O, De Buck E, Van Wijngaerden E. Lyme disease in Western Europe: an emerging problem? A systematic review. Acta Clin Belg. Epub ahead of print 18 November 2019. DOI: 10.1080/17843286.2019.1694293. - DOI - PubMed

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