Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2021 Apr 3;17(4):1190-1195.
doi: 10.1080/21645515.2020.1806672. Epub 2020 Sep 11.

Long-term persistence of anti-HBs after hepatitis B vaccination among isolated anti-HBc positive adults in China: 8-years results

Wen Ren  1 , Jing Li  2 , Ruidong Cheng  3 , Zikang Wu  4 , Ying Liu  1 , Yan Qiu  1 , Jun Yao  5 , Jingjing Ren  1
Affiliations

Long-term persistence of anti-HBs after hepatitis B vaccination among isolated anti-HBc positive adults in China: 8-years results

Wen Ren et al. Hum Vaccin Immunother. .

Abstract

The long-term persistence of hepatitis B surface antibody (anti-HBs) after hepatitis B vaccination among adults harboring isolated hepatitis B core antibody (anti-HBc) is not yet clarified. The present study aimed to assess the immunogenicity and persistence of antibodies in adults 8 years after vaccination. A total of 309 participants including 94 participants in the isolated anti-HBs group and 215 in the control group were recruited in this study. All subjects received three doses of hepatitis B vaccine (20 μg) at 0, 1, and 12 months, followed by testing for serological responses 1 month after the third vaccination. Subsequently, 154 participants were excluded because their anti-HBs data of 8 y after the first vaccination were missing. The prevalence of isolated anti-HBc was about 11.5%, the positive seroprotection rate was 72%, and the geometric mean titer (GMT) value of anti-HBs titer was 24.55 mIU/mL in the isolated anti-HBc group 8 y after three doses of vaccination. No significant difference was detected in the positive seroprotection rate (P = .434) and the GMT values of anti-HBs titers (P = .674) between the isolated anti-HBc and control groups after 8 y. In conclusion, isolated anti-HBc-positive subjects could achieve satisfactory long-term immune effects after hepatitis B vaccination. The GMT values of anti-HBs titers were lower than those of the control group at 1 month, but no significant difference was detected after 8 years.

Keywords: Hepatitis B virus; isolated anti-HBc; vaccine.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Study flowchart
Figure 2.
Figure 2.
Proportion of different immune response in the isolated anti-HBc and control groups
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. World Health Organization . Global hepatitis report, 19 April 2017. [OL]. [cited 2020 May 5]. https://www.who.int/publications-detail/global-hepatitis-report-2017.
    1. World Health Organization . Hepatitis B [OL]. 18 July 2019. [cited 2020 May 5]. https://www.who.int/news-room/fact-sheets/detail/hepatitis-b.
    1. Wang FZ, Zheng W, Su XJ, Miao N, Zhang GM, Yin ZD.. Achievements and prospects for hepatitis B prevention and control in China. Chin J Vacc Immun. 2019;25:487–92. (In Chinese).
    1. Jing W, Liu J, Liu M. Eliminating mother-to-child transmission of HBV: progress and challenges in China. Front Med PMID: 31974872. 2020;14(1):21–29. doi:10.1007/s11684-020-0744-2. - DOI - PubMed
    1. Ren W, Ren JJ, Wu Z, Shen LZ, Shan H, Dai XW, Li J,Liu Y,Qiu Y, Yao J, et al. Long-term persistence of anti-HBs after hepatitis B vaccination among adults: 8-year results. Hum Vaccin Immunother. 2020;16(3):687–92. doi:10.1080/21645515.2019.1666612. PMID: 31526223. - DOI - PMC - PubMed

Publication types

Substances

Grants and funding

This study was supported by the National Scientific and Technological Major Project of China [2018ZX10715014, 2017ZX10105001, 2014ZX10004008, 2013ZX10004-904, 2011ZX10004-901].