Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module
- PMID: 32911111
- DOI: 10.1016/j.bbagrm.2020.194630
Function and regulation of the Spt-Ada-Gcn5-Acetyltransferase (SAGA) deubiquitinase module
Abstract
The Spt-Ada-Gcn5 Acetyltransferase (SAGA) chromatin modifying complex is a critical regulator of gene expression and is highly conserved across species. Subunits of SAGA arrange into discrete modules with lysine aceyltransferase and deubiquitinase activities housed separately. Mutation of the SAGA deubiquitinase module can lead to substantial biological misfunction and diseases such as cancer, neurodegeneration, and blindness. Here, we review the structure and functions of the SAGA deubiquitinase module and regulatory mechanisms acting to control these.
Keywords: Cancer; Cytoskeleton; Deubiquitinase; Gene regulation; Neurodegeneration; Polyglutamine expansion; SAGA complex.
Published by Elsevier B.V.
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