Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

doi:10.1002/anie.202010281

Review

. 2021 Apr 6;60(15):8018-8034.

doi: 10.1002/anie.202010281. Epub 2020 Oct 13.

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

Dan Wu¹, Sheng Wang², Guocan Yu³, Xiaoyuan Chen^{3

4}

Affiliations

¹ College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
² School of Life Sciences, Tianjin University and Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin, 300072, P. R. China.
³ Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, 20892, USA.
⁴ Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, 117597, Singapore.

PMID: 32894628
DOI: 10.1002/anie.202010281

Review

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

Dan Wu et al. Angew Chem Int Ed Engl. 2021.

. 2021 Apr 6;60(15):8018-8034.

doi: 10.1002/anie.202010281. Epub 2020 Oct 13.

Authors

Dan Wu¹, Sheng Wang², Guocan Yu³, Xiaoyuan Chen^{3

4}

Affiliations

¹ College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, 310014, P. R. China.
² School of Life Sciences, Tianjin University and Tianjin Engineering Center of Micro-Nano Biomaterials and Detection-Treatment Technology, Tianjin, 300072, P. R. China.
³ Laboratory of Molecular Imaging and Nanomedicine, National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health, Bethesda, Maryland, 20892, USA.
⁴ Yong Loo Lin School of Medicine and Faculty of Engineering, National University of Singapore, Singapore, 117597, Singapore.

PMID: 32894628
DOI: 10.1002/anie.202010281

Abstract

Pyroptosis, a unique form of programmed cell death (PCD) that is characterized by DNA fragmentation, chromatin condensation, cellular swelling with big bubbles, and leakage of cell content, has been proven to have a close relationship with human diseases, such as inflammatory diseases and malignant tumors. Since a new gasdermin-D (GSDMD) protein was identified in 2015, various strategies have been developed to induce pyroptosis for cancer therapy, including ions, small-molecule drugs and nanomaterials. Although there are a number of reviews about the close relationship between the pyroptosis mechanism and the occurrence of various cancers, a summary covering recent progress in the field of nanomedicines in pyroptosis-based cancer therapy has not yet been presented. Therefore, it is urgent to fill this gap and light up future directions for the use of this powerful tool to combat cancer. In this Minireview, recent progress in cancer treatment based on pyroptosis induced by nanoparticles will be described in detail, the design highlights and the therapeutic advantages are emphasized, and future perspectives in this emerging area are proposed.

Keywords: cancer therapy; nanomaterials; programmed cell death; pyroptosis; toxicological assessment.

PubMed Disclaimer

Cited by

Platelets camouflaged nanovehicle improved bladder cancer immunotherapy by triggering pyroptosis.
Tian J, Gao M, Zhu J, Xu H, Ji H, Xia D, Wang X. Tian J, et al. Theranostics. 2024 Oct 14;14(17):6692-6707. doi: 10.7150/thno.99040. eCollection 2024. Theranostics. 2024. PMID: 39479459 Free PMC article.
Cytosolic escape of mitochondrial DNA triggers cGAS-STING-NLRP3 axis-dependent nucleus pulposus cell pyroptosis.
Zhang W, Li G, Luo R, Lei J, Song Y, Wang B, Ma L, Liao Z, Ke W, Liu H, Hua W, Zhao K, Feng X, Wu X, Zhang Y, Wang K, Yang C. Zhang W, et al. Exp Mol Med. 2022 Feb;54(2):129-142. doi: 10.1038/s12276-022-00729-9. Epub 2022 Feb 10. Exp Mol Med. 2022. PMID: 35145201 Free PMC article.
Tumor Microenvironment Regulation and Cancer Targeting Therapy Based on Nanoparticles.
Han S, Chi Y, Yang Z, Ma J, Wang L. Han S, et al. J Funct Biomater. 2023 Feb 28;14(3):136. doi: 10.3390/jfb14030136. J Funct Biomater. 2023. PMID: 36976060 Free PMC article. Review.
Unlocking the potential of pyroptosis in tumor immunotherapy: a new horizon in cancer treatment.
Yin Q, Song SY, Bian Y, Wang Y, Deng A, Lv J, Wang Y. Yin Q, et al. Front Immunol. 2024 Jun 14;15:1381778. doi: 10.3389/fimmu.2024.1381778. eCollection 2024. Front Immunol. 2024. PMID: 38947336 Free PMC article. Review.
A mitochondria-anchored supramolecular photosensitizer as a pyroptosis inducer for potent photodynamic therapy and enhanced antitumor immunity.
Wang H, Jing G, Niu J, Yang L, Li Y, Gao Y, Wang H, Xu X, Qian Y, Wang S. Wang H, et al. J Nanobiotechnology. 2022 Dec 3;20(1):513. doi: 10.1186/s12951-022-01719-9. J Nanobiotechnology. 2022. PMID: 36463229 Free PMC article.

See all "Cited by" articles

References

1. None
1. F. Bray, A. Jemal, N. Grey, J. Ferlay, D. Forman, Lancet Oncol. 2012, 13, 790-801;
1. D. S. Dizon, L. Krilov, E. Cohen, T. Gangadhar, P. A. Ganz, T. A. Hensing, S. Hunger, S. S. Krishnamurthi, A. B. Lassman, M. J. Markham, E. Mayer, M. Neuss, S. K. Pal, L. C. Richardson, R. Schilsky, G. K. Schwartz, D. R. Spriggs, M. A. Villalona-Calero, G. Villani, G. Masters, J. Clin. Oncol. 2016, 34, 987-1011.
1. None
1. H. Okada, T. W. Mak, Nat. Rev. Cancer 2004, 4, 592-603;

Publication types

Actions
Actions
Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions
Actions

Grants and funding

ZIA EB000073/EB/NIBIB NIH HHS/United States

LinkOut - more resources

Full Text Sources
- Wiley
Miscellaneous
- NCI CPTAC Assay Portal

[1] None

[2] None

[3] F. Bray, A. Jemal, N. Grey, J. Ferlay, D. Forman, Lancet Oncol. 2012, 13, 790-801;

[4] F. Bray, A. Jemal, N. Grey, J. Ferlay, D. Forman, Lancet Oncol. 2012, 13, 790-801;

[5] D. S. Dizon, L. Krilov, E. Cohen, T. Gangadhar, P. A. Ganz, T. A. Hensing, S. Hunger, S. S. Krishnamurthi, A. B. Lassman, M. J. Markham, E. Mayer, M. Neuss, S. K. Pal, L. C. Richardson, R. Schilsky, G. K. Schwartz, D. R. Spriggs, M. A. Villalona-Calero, G. Villani, G. Masters, J. Clin. Oncol. 2016, 34, 987-1011.

[6] D. S. Dizon, L. Krilov, E. Cohen, T. Gangadhar, P. A. Ganz, T. A. Hensing, S. Hunger, S. S. Krishnamurthi, A. B. Lassman, M. J. Markham, E. Mayer, M. Neuss, S. K. Pal, L. C. Richardson, R. Schilsky, G. K. Schwartz, D. R. Spriggs, M. A. Villalona-Calero, G. Villani, G. Masters, J. Clin. Oncol. 2016, 34, 987-1011.

[7] None

[8] None

[9] H. Okada, T. W. Mak, Nat. Rev. Cancer 2004, 4, 592-603;

[10] H. Okada, T. W. Mak, Nat. Rev. Cancer 2004, 4, 592-603;

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

Affiliations

Cell Death Mediated by the Pyroptosis Pathway with the Aid of Nanotechnology: Prospects for Cancer Therapy

Authors

Affiliations

Abstract

Similar articles

Cited by

References

Publication types

MeSH terms

Substances

Grants and funding

LinkOut - more resources

Full Text Sources

Miscellaneous