Nanotherapeutics in Neuropathologies: Obstacles, Challenges and Recent Advancements in CNS Targeted Drug Delivery Systems
- PMID: 32851949
- PMCID: PMC8573747
- DOI: 10.2174/1570159X18666200807143526
Nanotherapeutics in Neuropathologies: Obstacles, Challenges and Recent Advancements in CNS Targeted Drug Delivery Systems
Abstract
Neurology and associated nanotherapeutics are a complex field in terms of therapeutics and neurological disorder complexity. The brain is an intricate appendage and requires more precise embattled treatment for the particular diseases and hence it is a broad scale for developing more targeted drug deliveries. The brain is one of the most inaccessible tissues of the body due to the existence of the blood-brain barrier (BBB), thus delivery of drugs inside the brain is a striking dare and it is also tricky to treat central nervous system (CNS) complications pharmacologically. The therapeutic aspiration is to accomplish the lowest drug meditation in the brain tissues so as to gain favoured therapeutic results. To devastate this obstacle, nanotechnology is engaged in the field of targeted brain drug delivery and neuropathology targeting. These carriers hold myriad abilities as they may augment the drug delivery into the brain by shielding them from degradation and prolonging their transmission in the blood, as well as promoting their transport through the BBB. Nanopharmaceuticals are quickly sprouting as a new avenue that is engaged with the drug-loaded nanocarriers to demonstrate unique physicochemical properties and tiny size range for penetrating the central nervous system. The enchantment behind their therapeutic achievement is the condensed drug dose and inferior toxicity, whereby restricting the therapeutic compound to the specific site. Therefore, in this article, we have tried to recapitulate the advances of the novel scopes for the brain targeted drug delivery for complex neurological disorders.
Keywords: Brain barriers; blood brain barrier; brain tumour barriers; nanocarriers; neuro-nano therapeutics; neuropathology.
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Figures
Similar articles
-
Cellular and Molecular Targeted Drug Delivery in Central Nervous System Cancers: Advances in Targeting Strategies.Curr Top Med Chem. 2020;20(30):2762-2776. doi: 10.2174/1568026620666200826122402. Curr Top Med Chem. 2020. PMID: 32851962 Review.
-
Drug delivery across the blood-brain barrier: recent advances in the use of nanocarriers.Nanomedicine (Lond). 2020 Jan;15(2):205-214. doi: 10.2217/nnm-2019-0367. Epub 2020 Jan 9. Nanomedicine (Lond). 2020. PMID: 31916480 Review.
-
Application of Therapeutic Nanoplatforms as a Potential Candidate for the Treatment of CNS Disorders: Challenges and Possibilities.Curr Pharm Des. 2022;28(33):2742-2757. doi: 10.2174/1381612828666220729104433. Curr Pharm Des. 2022. PMID: 35909283 Review.
-
Strategies for transporting nanoparticles across the blood-brain barrier.Biomater Sci. 2016 Feb;4(2):219-29. doi: 10.1039/c5bm00383k. Biomater Sci. 2016. PMID: 26646694 Review.
-
Targeting central nervous system pathologies with nanomedicines.J Drug Target. 2019 Jun-Jul;27(5-6):542-554. doi: 10.1080/1061186X.2018.1533556. Epub 2018 Oct 18. J Drug Target. 2019. PMID: 30296187 Review.
Cited by
-
Targeting Neuroimmune Interactions in Diabetic Neuropathy with Nanomedicine.Antioxid Redox Signal. 2022 Jan;36(1-3):122-143. doi: 10.1089/ars.2021.0123. Antioxid Redox Signal. 2022. PMID: 34416821 Free PMC article.
-
Trends on Novel Targets and Nanotechnology-Based Drug Delivery System in the Treatment of Parkinson's disease: Recent Advancement in Drug Development.Curr Drug Targets. 2024;25(15):987-1011. doi: 10.2174/0113894501312703240826070530. Curr Drug Targets. 2024. PMID: 39313872 Review.
-
Characterization of prevalent tyrosine kinase inhibitors and their challenges in glioblastoma treatment.Front Chem. 2024 Jan 8;11:1325214. doi: 10.3389/fchem.2023.1325214. eCollection 2023. Front Chem. 2024. PMID: 38264122 Free PMC article. Review.
-
Nano biomaterials based strategies for enhanced brain targeting in the treatment of neurodegenerative diseases: an up-to-date perspective.J Nanobiotechnology. 2023 Dec 13;21(1):477. doi: 10.1186/s12951-023-02250-1. J Nanobiotechnology. 2023. PMID: 38087359 Free PMC article. Review.
-
Nanogels as Novel Nanocarrier Systems for Efficient Delivery of CNS Therapeutics.Front Bioeng Biotechnol. 2022 Jul 19;10:954470. doi: 10.3389/fbioe.2022.954470. eCollection 2022. Front Bioeng Biotechnol. 2022. PMID: 35928954 Free PMC article. Review.
References
MeSH terms
LinkOut - more resources
Full Text Sources
Other Literature Sources