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. 2020 Jul 31:7:418.
doi: 10.3389/fvets.2020.00418. eCollection 2020.

Effect of the Single and Combined Use of Curcumin and Piperine on Growth Performance, Intestinal Barrier Function, and Antioxidant Capacity of Weaned Wuzhishan Piglets

Liguang Shi  1 , Wenjuan Xun  2 , Weiqi Peng  1 , Haichao Hu  1 , Ting Cao  1 , Guanyu Hou  1
Affiliations

Effect of the Single and Combined Use of Curcumin and Piperine on Growth Performance, Intestinal Barrier Function, and Antioxidant Capacity of Weaned Wuzhishan Piglets

Liguang Shi et al. Front Vet Sci. .

Abstract

This study was conducted to evaluate effects of the single and combined use of curcumin (CUR) and piperine (PIP) on performance, intestinal barrier function, and antioxidant capacity of weaned piglets. A total of 50 Wuzhishan piglets weaned at 35 days of age were randomly assigned to five groups receiving a corn-soybean basal diet (CON), the basal diet supplemented with 50 mg/kg piperine, 200 mg/kg curcumin (low-CUR), 200 mg/kg curcumin + 50 mg/kg piperine (PIP + CUR), and 300 mg/kg curcumin (high-CUR), respectively. The results showed that the feed/gain ratio (F/G) and plasma d-lactate and diamine oxidase activity (DAO) of the CUR + PIP and high-CUR groups were lower than those of the CON group (all P < 0.05), while the jejunum and ileum villus height, the villus height/crypt depth ratio, and the messenger RNA (mRNA) expression levels of occludin, claudin-1, and zonula occluden-1 in jejunal and ileal mucosa were higher in the CUR + PIP and high-CUR groups than in the CON group (all P < 0.05). Moreover, the piglets in the CUR + PIP and high-CUR groups had higher serum and intestinal mucosa activity of superoxide dismutase and glutathione peroxidase and lower malonaldehyde concentration than piglets in the CON group (all P < 0.05). The above parameters were not significantly different between the CUR + PIP and high-CUR groups (P > 0.05). In conclusion, the combination of CUR and PIP seemed to be as advantageous as high-CUR to piglets, but it was more effective than the single use of CUR and PIP. These data indicated that the basal diet supplemented with CUR + PIP or high-CUR could improve the intestinal permeability and suppress oxidative stress of weaned Wuzhishan piglets.

Keywords: antioxidant capacity; curcumin; growth performance; intestinal permeability; piperine; weaned piglet.

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Figures

Figure 1
Figure 1
Effect of curcumin (CUR) and piperine (PIP) on messenger RNA (mRNA) expression of tight junction protein in (A) jejunal mucosa and (B) ileal mucosa of weaned Wuzhishan piglets. Values are expressed as mean ± standard deviations (n = 6). abMeans values within different letters differ significantly (P < 0.05). CON, a corn–soybean basal diet; PIP, low-CUR, PIP + CUR, and high-CUR, the basal diet supplemented with 50 mg/kg piperine, 200 mg/kg curcumin, 200 mg/kg curcumin + 50 mg/kg piperine, and 300 mg/kg curcumin, respectively.
Figure 2
Figure 2
Effect of curcumin (CUR) and piperine (PIP) on messenger RNA (mRNA) expression of cytokines in (A) jejunal and (B) ileal mucosa of weaned Wuzhishan piglets. Values are means (n = 6), and standard deviations represented by vertical bars. CON, a corn–soybean basal diet; PIP, low-CUR, PIP + CUR, and high-CUR, the basal diet supplemented with 50 mg/kg piperine, 200 mg/kg curcumin, 200 mg/kg curcumin + 50 mg/kg piperine, and 300 mg/kg curcumin, respectively. Dietary Rice Improves Growth Performance, Mucosal Enzyme Activities, and Plasma Urea Nitrogen in Weaning Piglets. Effects of Dietary Methionine Supplementation on Growth Performance, Intestinal Morphology, Antioxidant Capacity, and Immune Function in Intra-Uterine Growth-Retarded Suckling Piglets. Comparative Effects of Dietary Supplementations With Sodium Butyrate, Medium-Chain Fatty Acids, and n-3 Polyunsaturated Fatty Acids in Late Pregnancy, and Lactation on the Reproductive Performance of Sows and Growth Performance of Suckling Piglets. Effects of Composite Antimicrobial Peptide on Growth Performance and Health in Weaned Piglets.
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