Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020;6(3):96-107.
doi: 10.1007/s40778-020-00177-z. Epub 2020 Aug 17.

Common Sources of Inflammation and Their Impact on Hematopoietic Stem Cell Biology

Daniel Hormaechea-Agulla #  1 , Duy T Le #  1   2 , Katherine Y King  1   2
Affiliations
Review

Common Sources of Inflammation and Their Impact on Hematopoietic Stem Cell Biology

Daniel Hormaechea-Agulla et al. Curr Stem Cell Rep. 2020.

Abstract

Purpose of review: Inflammatory signals have emerged as critical regulators of hematopoietic stem cell (HSC) function. Specifically, HSCs are highly responsive to acute changes in systemic inflammation and this influences not only their division rate but also their lineage fate. Identifying how inflammation regulates HSCs and shapes the blood system is crucial to understanding the mechanisms underpinning these processes, as well as potential links between them.

Recent findings: A widening array of physiologic and pathologic processes involving heightened inflammation are now recognized to critically affect HSC biology and blood lineage production. Conditions documented to affect HSC function include not only acute and chronic infections but also autoinflammatory conditions, irradiation injury, and physiologic states such as aging and obesity.

Summary: Recognizing the contexts during which inflammation affects primitive hematopoiesis is essential to improving our understanding of HSC biology and informing new therapeutic interventions against maladaptive hematopoiesis that occurs during inflammatory diseases, infections, and cancer-related disorders.

Keywords: Bone marrow; Hematopoiesis; Infectious diseases; Inflammatory conditions; Pro-inflammatory cytokines.

PubMed Disclaimer

Conflict of interest statement

Conflict of InterestKatherine King, Daniel Hormaechea Agulla, and Duy Le declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Main sources of inflammation that affect HSC biology
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. King KY, Goodell MA. Inflammatory modulation of HSCs: viewing the HSC as a foundation for the immune response. Nat Rev Immunol. 2011;11(10):685–692. - PMC - PubMed
    1. Chavakis T, Mitroulis I, Hajishengallis G. Hematopoietic progenitor cells as integrative hubs for adaptation to and fine-tuning of inflammation. Nat Immunol. 2019;20(7):802–811. - PMC - PubMed
    1. Kovtonyuk LV, et al. Inflamm-aging of hematopoiesis, hematopoietic stem cells, and the bone marrow microenvironment. Front Immunol. 2016;7:502. - PMC - PubMed
    1. Takizawa H, et al. Pathogen-induced TLR4-TRIF innate immune signaling in hematopoietic stem cells promotes proliferation but reduces competitive fitness. Cell Stem Cell. 2017;21(2):225–240. - PubMed
    1. Boettcher S, et al. Endothelial cells translate pathogen signals into G-CSF-driven emergency granulopoiesis. Blood. 2014;124(9):1393–1403. - PMC - PubMed

LinkOut - more resources