Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

doi:10.3390/diagnostics10080601

Review

. 2020 Aug 17;10(8):601.

doi: 10.3390/diagnostics10080601.

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

Małgorzata Krzystek-Korpacka¹, Radosław Kempiński², Mariusz A Bromke¹, Katarzyna Neubauer²

Affiliations

¹ Department of Medical Biochemistry, Wroclaw Medical University, Chałubińskiego 10, 50-368 Wroclaw, Poland.
² Department of Gastroenterology and Hepatology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

PMID: 32824619
PMCID: PMC7459713
DOI: 10.3390/diagnostics10080601

Review

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

Małgorzata Krzystek-Korpacka et al. Diagnostics (Basel). 2020.

. 2020 Aug 17;10(8):601.

doi: 10.3390/diagnostics10080601.

Authors

Małgorzata Krzystek-Korpacka¹, Radosław Kempiński², Mariusz A Bromke¹, Katarzyna Neubauer²

Affiliations

¹ Department of Medical Biochemistry, Wroclaw Medical University, Chałubińskiego 10, 50-368 Wroclaw, Poland.
² Department of Gastroenterology and Hepatology, Wroclaw Medical University, Borowska 213, 50-556 Wroclaw, Poland.

PMID: 32824619
PMCID: PMC7459713
DOI: 10.3390/diagnostics10080601

Abstract

Precise diagnostic biomarker in inflammatory bowel diseases (IBD) is still missing. We conducted a comprehensive overview of oxidative stress markers (OSMs) as potential diagnostic, differential, progression, and prognostic markers in IBD. A Pubmed, Web of Knowledge, and Scopus search of original articles on OSMs in IBD, published between January 2000 and April 2020, was conducted. Out of 874 articles, 79 eligible studies were identified and used to prepare the interpretative synthesis. Antioxidants followed by lipid peroxidation markers were the most popular and markers of oxidative DNA damage the least popular. There was a disparity in the number of retrieved papers evaluating biomarkers in the adult and pediatric population (n = 6). Of the reviewed OSMs, a promising performance has been reported for serum total antioxidant status as a mucosal healing marker, mucosal 8-OHdG as a progression marker, and for multi-analyte panels of lipid peroxidation products assessed non-invasively in breath as diagnostic and differential markers in the pediatric population. Bilirubin, in turn, was the only validated marker. There is a desperate need for non-invasive biomarkers in IBD which, however, will not be met in the near future by oxidative stress markers as they are promising but mostly at the early research phase of discovery.

Keywords: Crohn’s disease; antioxidants; biomarkers; lipid peroxidation; mucosal healing; ulcerative colitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

**Figure 1**
Flowchart presenting the selection process. IBD, inflammatory bowel diseases.

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References

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1. Kaplan G.G. The Global Burden of IBD: From 2015 to 2025. Nat. Rev. Gastroenterol. Hepatol. 2015;12:720–727. doi: 10.1038/nrgastro.2015.150. - DOI - PubMed
1. Ng S.C., Shi H.Y., Hamidi N., Underwood F.E., Tang W., Benchimol E.I., Panaccione R., Ghosh S., Wu J.C.Y., Chan F.K.L., et al. Worldwide Incidence and Prevalence of Inflammatory Bowel Disease in the 21st Century: A Systematic Review of Population-Based Studies. Lancet. 2018;390:2769–2778. doi: 10.1016/S0140-6736(17)32448-0. - DOI - PubMed

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[1] Kim D.H., Cheon J.H. Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies. Immune Netw. 2017;17:25–40. doi: 10.4110/in.2017.17.1.25. - DOI - PMC - PubMed

[2] Kim D.H., Cheon J.H. Pathogenesis of Inflammatory Bowel Disease and Recent Advances in Biologic Therapies. Immune Netw. 2017;17:25–40. doi: 10.4110/in.2017.17.1.25. - DOI - PMC - PubMed

[3] Cantoro L., Di Sabatino A., Papi C., Margagnoni G., Ardizzone S., Giuffrida P., Giannarelli D., Massari A., Monterubbianesi R., Lenti M.V., et al. The Time Course of Diagnostic Delay in Inflammatory Bowel Disease Over the Last Sixty Years: An Italian Multicentre Study. J. Crohn’s Colitis. 2017;11:975–980. doi: 10.1093/ecco-jcc/jjx041. - DOI - PubMed

[4] Cantoro L., Di Sabatino A., Papi C., Margagnoni G., Ardizzone S., Giuffrida P., Giannarelli D., Massari A., Monterubbianesi R., Lenti M.V., et al. The Time Course of Diagnostic Delay in Inflammatory Bowel Disease Over the Last Sixty Years: An Italian Multicentre Study. J. Crohn’s Colitis. 2017;11:975–980. doi: 10.1093/ecco-jcc/jjx041. - DOI - PubMed

[5] Coward S., Clement F., Benchimol E.I., Bernstein C.N., Avina-Zubieta J.A., Bitton A., Carroll M.W., Hazlewood G., Jacobson K., Jelinski S., et al. Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-Based Data. Gastroenterology. 2019;156:1345–1353.e4. doi: 10.1053/j.gastro.2019.01.002. - DOI - PubMed

[6] Coward S., Clement F., Benchimol E.I., Bernstein C.N., Avina-Zubieta J.A., Bitton A., Carroll M.W., Hazlewood G., Jacobson K., Jelinski S., et al. Past and Future Burden of Inflammatory Bowel Diseases Based on Modeling of Population-Based Data. Gastroenterology. 2019;156:1345–1353.e4. doi: 10.1053/j.gastro.2019.01.002. - DOI - PubMed

[7] Kaplan G.G. The Global Burden of IBD: From 2015 to 2025. Nat. Rev. Gastroenterol. Hepatol. 2015;12:720–727. doi: 10.1038/nrgastro.2015.150. - DOI - PubMed

[8] Kaplan G.G. The Global Burden of IBD: From 2015 to 2025. Nat. Rev. Gastroenterol. Hepatol. 2015;12:720–727. doi: 10.1038/nrgastro.2015.150. - DOI - PubMed

[9] Ng S.C., Shi H.Y., Hamidi N., Underwood F.E., Tang W., Benchimol E.I., Panaccione R., Ghosh S., Wu J.C.Y., Chan F.K.L., et al. Worldwide Incidence and Prevalence of Inflammatory Bowel Disease in the 21st Century: A Systematic Review of Population-Based Studies. Lancet. 2018;390:2769–2778. doi: 10.1016/S0140-6736(17)32448-0. - DOI - PubMed

[10] Ng S.C., Shi H.Y., Hamidi N., Underwood F.E., Tang W., Benchimol E.I., Panaccione R., Ghosh S., Wu J.C.Y., Chan F.K.L., et al. Worldwide Incidence and Prevalence of Inflammatory Bowel Disease in the 21st Century: A Systematic Review of Population-Based Studies. Lancet. 2018;390:2769–2778. doi: 10.1016/S0140-6736(17)32448-0. - DOI - PubMed

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Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

Affiliations

Oxidative Stress Markers in Inflammatory Bowel Diseases: Systematic Review

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