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. 2020 Aug 14;25(16):3700.
doi: 10.3390/molecules25163700.

Annexin A1: A Bane or a Boon in Cancer? A Systematic Review

Thanusha Ganesan  1 , Ajantha Sinniah  1 , Zaridatul Aini Ibrahim  1 , Zamri Chik  1 , Mohammed Abdullah Alshawsh  1
Affiliations

Annexin A1: A Bane or a Boon in Cancer? A Systematic Review

Thanusha Ganesan et al. Molecules. .

Abstract

Annexin A1 has been extensively investigated as an anti-inflammatory protein, but its role in different types of cancer has not been consolidated in a single systematic review to date. Thus, the aim of this paper is to systematically review and critically analyse 18 studies (in-vivo and in-vitro) to consolidate, in a concerted manner, all the information on differential expression of Annexin A1 in different types of cancer and the role this protein plays in tumorigenesis. Pubmed, Scopus, Web of Science, and ScienceDirect were used for the literature search and the keywords used are "annexin A1," "lipocortin 1," "cancer," "malignancy," "neoplasm," "neoplasia," and "tumor." A total of 1128 articles were retrieved by implementing a standard search strategy subjected to meticulous screening processes and 442 articles were selected for full article screening. A total of 18 articles that adhered to the inclusion criteria were included in the systematic review and these articles possessed low to moderate bias. These studies showed a strong correlation between Annexin A1 expression and cancer progression via modulation of various cancer-associated pathways. Differential expression of Annexin A1 is shown to play a role in cellular proliferation, metastasis, lymphatic invasion, and development of resistance to anti-cancer treatment. Meta-analysis in the future may provide a statistically driven association between Annexin A1 expression and malignancy progression.

Keywords: Annexin A1; cancer; gene expression; lipocortin 1; systematic review.

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Conflict of interest statement

The authors declare no potential conflict of interest.

Figures

Figure 1
Figure 1
PRISMA flow diagram of study selection process.
Figure 2
Figure 2
Schematic representation of differential roles of Anx-A1 in various signaling pathways contributing to the pathophysiology of cancer [47,48,49,50].
See this image and copyright information in PMC

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