Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Dec 1:164:1960-1972.
doi: 10.1016/j.ijbiomac.2020.08.053. Epub 2020 Aug 12.

Nanosheets-incorporated bio-composites containing natural and synthetic polymers/ceramics for bone tissue engineering

S Pranav Adithya  1 , D Saleth Sidharthan  1 , R Abhinandan  1 , K Balagangadharan  1 , N Selvamurugan  2
Affiliations
Review

Nanosheets-incorporated bio-composites containing natural and synthetic polymers/ceramics for bone tissue engineering

S Pranav Adithya et al. Int J Biol Macromol. .

Abstract

Bone is a highly integrative and dynamic tissue of the human body that is regularly modeled and remodeled by bone cells such as osteoblasts and osteoclasts. When a fraction of a bone is damaged or deformed, stem cells and bone cells under the influence of several signaling pathways regulate bone regeneration at the particular locale, but in a dilatory manner. To overcome this problem, the field of bone tissue engineering (BTE) utilizes various bio-composite scaffolds that incorporate cells and appropriate growth factors to promote osteogenesis. Nanosheets are in two-dimensional (2D)-atomic structures, and metallic and non-metallic nanosheets play a keen role in biomedical applications, including BTE. Due to their intrinsic mechanical properties such as durability and flexibility, nanosheets strengthen the bio-composite scaffolds containing natural polymers (chitosan, gelatin, and collagen), synthetic polymers, bio-ceramics, and bio-glasses. Incorporating nanosheets into bio-composites promotes the bio-functionality of the cells, such as cell adhesion and osteoblast differentiation. Hence, this review was aimed to provide a detailed study on the nanosheets-incorporated bio-composites and their properties for BTE applications.

Keywords: Bone tissue engineering; Chitosan; Gelatin; Nanosheets; Osteoblast.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

LinkOut - more resources