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Meta-Analysis
. 2021 May 17;27(6):947-955.
doi: 10.1093/ibd/izaa189.

Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Austin Lin  1 , Hannah Roth  1 , Adjoa Anyane-Yeboa  2 , David T Rubin  3 , Sonali Paul  3
Affiliations
Meta-Analysis

Prevalence of Nonalcoholic Fatty Liver Disease in Patients With Inflammatory Bowel Disease: A Systematic Review and Meta-analysis

Austin Lin et al. Inflamm Bowel Dis. .

Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) is a significant public health burden, with up to 30% of the US population affected. The prevalence of NAFLD among inflammatory bowel disease (IBD) patients is unknown. Understanding risk factors for NAFLD in IBD patients has implications in the treatment of these patients. The purpose of this study was to determine the prevalence of NAFLD among IBD patients and to identify risk factors associated with NAFLD development.

Methods: Embase and MEDLINE databases were searched using Medical Subject Headlines to find studies that assessed the prevalence of NAFLD among IBD patients. Twenty-seven English-language research abstracts/articles were identified between January 2005 and April 2018. Meta-analyses were performed using random-effects models. Prevalence of NAFLD among IBD patients was compared with prevalence of NAFLD in the general population.

Results: Based on data pooled from all 27 studies, the prevalence of NAFLD among IBD patients was 32% (95% CI, 24%-40%) with substantial heterogeneity (I2 = 98%). The prevalence of NAFLD among IBD patients (32%) is statistically significantly higher than the prevalence of NAFLD in the general population (25.2%; P < 0.001). Factors associated with the development of NAFLD among IBD patients included age, BMI, diabetes, IBD duration, and prior history of bowel resection.

Conclusions: There is a higher prevalence of NAFLD among IBD patients compared with the general population. Previous treatment regimens may be a risk factor for the development of NAFLD. Future studies are needed to further clarify these risk factors and determine screening recommendations.

Keywords: inflammatory bowel disease; meta-analysis; nonalcoholic fatty liver disease.

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Figures

FIGURE 1.
FIGURE 1.
Summary of evidence search and selection.
FIGURE 2.
FIGURE 2.
Prevalence of NAFLD in IBD patients.
FIGURE 3.
FIGURE 3.
Prevalence of NAFLD in IBD patients by NAFLD diagnosis method.
See this image and copyright information in PMC

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