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. 2020 Jul 31:18:16.
doi: 10.1186/s13053-020-00147-w. eCollection 2020.

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Katarzyna Białkowska  1 , Wojciech Marciniak  2 , Magdalena Muszyńska  2 , Piotr Baszuk  1 , Satish Gupta  3 , Katarzyna Jaworska-Bieniek  1 , Grzegorz Sukiennicki  1 , Katarzyna Durda  1 , Tomasz Gromowski  1 , Marcin Lener  1 , Karolina Prajzendanc  1 , Alicja Łukomska  1 , Cezary Cybulski  1 , Tomasz Huzarski  1 , Jacek Gronwald  1 , Tadeusz Dębniak  1 , Jan Lubiński  1   2 , Anna Jakubowska  1   4
Affiliations

Polymorphisms in MMP-1, MMP-2, MMP-7, MMP-13 and MT2A do not contribute to breast, lung and colon cancer risk in polish population

Katarzyna Białkowska et al. Hered Cancer Clin Pract. .

Abstract

Background: Matrix metalloproteinases (MMPs) and metallothioneins (MTs) are Zinc-related proteins which are involved in processes crucial for carcinogenesis such as angiogenesis, proliferation and apoptosis. Several single nucleotide polymorphisms (SNPs) in MMPs and MTs that affect genes expression have been associated with cancer risk, including breast, lung and colon.

Methods: The study group consisted of 648 unselected patients (299 with breast cancer, 199 with lung cancer, 150 with colon cancer) and 648 unaffected individuals. Five SNPs, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A were genotyped and serum zinc (Zn) level was measured. The cancer risk was calculated using multivariable logistic regression with respect to Zn.

Results: None of the 5 tested polymorphisms showed a correlation with cancer risk in studied groups, although for MMP-2, MMP-7 and MT2A non-significant differences in genotypes frequencies among cases and controls were observed.

Conclusions: Analyses of polymorphisms, rs1799750 in MMP-1, rs243865 in MMP-2, rs11568818 in MMP-7, rs2252070 in MMP-13 and rs28366003 in MT2A in relation to serum Zn level did not show significant association with breast, lung and colon cancer risk among polish patients. Further studies are needed to verify this observation.

Keywords: Matrix metalloproteinases; Metallothioneins; Polymorphisms; Prostate cancer.

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Conflict of interest statement

Competing interestsJL is CEO of Read-Gene S.A. The authors WM, MM are employees of Read-Gene S.A. KB, PB, SG, KJB, GS, KD, TG, ML, KP, AŁ, CC, TH, JG, TD, AJ declare that they have no competing interests.

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