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. 2020 Nov;103(5):2108-2112.
doi: 10.4269/ajtmh.20-0515.

Evaluating Over-the-Counter Household Insecticide Aerosols for Rapid Vector Control of Pyrethroid-Resistant Aedes aegypti

Sergio Dzib-Florez  1 , Gustavo Ponce-García  2 , Anuar Medina-Barreiro  1 , Gabriela González-Olvera  1   3 , Yamili Contreras-Perera  1 , Felipe Del Castillo-Centeno  1 , Ahmed M M Ahmed  1   4 , Azael Che-Mendoza  1 , Philip J McCall  5 , Gonzalo Vazquez-Prokopec  6 , Pablo Manrique-Saide  1
Affiliations

Evaluating Over-the-Counter Household Insecticide Aerosols for Rapid Vector Control of Pyrethroid-Resistant Aedes aegypti

Sergio Dzib-Florez et al. Am J Trop Med Hyg. 2020 Nov.

Abstract

Vector control methods that mobilize and impact rapidly during dengue, Zika, and chikungunya outbreaks are urgently needed in urban contexts. We investigated whether one person using a handheld aerosolized insecticide could achieve efficacy levels comparable to targeted indoor residual spraying (TIRS), using pyrethroid-resistant Aedes aegypti in a semi-field setting with experimental houses in Mexico. The insecticide product (H24, a carbamate and pyrethroid mixture), available over-the-counter locally, was sprayed only on known Ae. aegypti-resting surfaces, for example, walls less than 1.5 m and dark hidden areas. In six identical houses with paired bedrooms, one bedroom was treated, and the other remained an untreated control. Each week for 8 weeks, 100 female pyrethroid-resistant Ae. aegypti were released in each bedroom and followed up daily. Mortality rates in treated bedrooms exceeded 90% for at least 2 weeks, and more than 80% (89.2; 95% CI: 79.98-98.35) for 3 weeks or more. Mortality rates in control houses were zero. Results demonstrate that the immediate impact of TIRS can be delivered by one person using existing products, at an estimated cost for the average household in Mexico of under US$3 per month. Triggered by early outbreak signs, dissemination via community hubs and mass/social media of instructions to treat the home immediately, with monthly re-treatment thereafter, provides a simple means to engage and empower householders. Compatible with integrated vector management strategies, it enables self-protection even if existing agencies falter, a situation exemplified by the potential impact on vector control of the restrictions imposed during the 2020 COVID-19 pandemic.

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Figures

Figure 1.
Figure 1.
(A) Layout of an experimental house, showing the positions and sizes of furniture in the identical bedrooms. All external and internal windows and doors were screened to prevent mosquito passage. A bucket (0.5 L water) and a 40-cm-diam. oscillating fan stabilized relative humidity and temperature in each bedroom. The interiors of all six experimental houses were identical. (B) Mortality of pyrethroid-resistant Aedes aegypti by targeted indoor residual spraying (TIRS) with a household aerosolized insecticide over time. Symbols denote sample means, and error bars are the standard error of the mean. D = day; W = weeks.
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