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Editorial
. 2020 Nov 15;202(10):1339-1341.
doi: 10.1164/rccm.202007-2632ED.

A New "TYK" Tok Era for the Study of Long Noncoding RNAs in Pulmonary Hypertension

Neha Hafeez  1 , Stephen Y Chan  2   3
Affiliations
Editorial

A New "TYK" Tok Era for the Study of Long Noncoding RNAs in Pulmonary Hypertension

Neha Hafeez et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
A new era for studies in long noncoding RNA (lncRNA) biology for pulmonary arterial hypertension. (A) Representation of TYKRIL (tyrosine kinase receptor–inducing lncRNA) function in the p53/PDGFRβ signaling axis under physiologic and pulmonary hypertension conditions. (B) Advancing methodologies for creating three in situ models to study human pathophysiology driven by nonconserved lncRNAs: precision-cut lung slices, humanized mouse models, and human organoid models. (C) Currently proposed therapeutic technologies and their drawbacks for inhibiting lncRNAs (Gapmers/antisense oligonucleotides [ASO] and CRISPR/Cas9 genome editing). Priorities for understanding lncRNA biology to develop more effective RNA therapies include systems biology analyses for defining RNA secondary structure, binding partners, and cell type–specific expression and function. 3D = three-dimensional.
See this image and copyright information in PMC

Comment on

  • Long Noncoding RNA TYKRIL Plays a Role in Pulmonary Hypertension via the p53-mediated Regulation of PDGFRβ.
    Zehendner CM, Valasarajan C, Werner A, Boeckel JN, Bischoff FC, John D, Weirick T, Glaser SF, Rossbach O, Jaé N, Demolli S, Khassafi F, Yuan K, de Jesus Perez VA, Michalik KM, Chen W, Seeger W, Guenther A, Wasnick RM, Uchida S, Zeiher AM, Dimmeler S, Pullamsetti SS. Zehendner CM, et al. Am J Respir Crit Care Med. 2020 Nov 15;202(10):1445-1457. doi: 10.1164/rccm.201910-2041OC. Am J Respir Crit Care Med. 2020. PMID: 32634060 Free PMC article.

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