Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity
- PMID: 3272175
- DOI: 10.1016/0896-6273(88)90192-4
Multiple products of the Drosophila Shaker gene may contribute to potassium channel diversity
Abstract
K+ channels are known through electrophysiology and pharmacology to be an exceptionally diverse group of channels. Molecular studies of the Shaker (Sh) locus in Drosophila have provided the first glimpse of K+ channel structure. The sequences of several Sh cDNA clones have been reported; none are identical. We have isolated and examined 18 additional Sh cDNAs in an attempt to understand the origin, extent, and significance of the variability. The diversity is extensive: we have already identified cDNAs representing at least nine distinct types, and Sh could potentially encode 24 or more products. This diversity, however, fits a simple pattern in which variable 3' and 5' ends are spliced onto a central constant region to yield different cDNA types. These different Sh cDNAs encode proteins with distinct structural features.
Similar articles
-
A distinct potassium channel polypeptide encoded by the Drosophila eag locus.Science. 1991 Jun 14;252(5012):1560-2. doi: 10.1126/science.1840699. Science. 1991. PMID: 1840699
-
Cloning of genomic and complementary DNA from Shaker, a putative potassium channel gene from Drosophila.Science. 1987 Aug 14;237(4816):749-53. doi: 10.1126/science.2441470. Science. 1987. PMID: 2441470
-
Molecular cloning of a member of a third class of Shaker-family K+ channel genes in mammals.Proc Natl Acad Sci U S A. 1990 Jul;87(13):5227-31. doi: 10.1073/pnas.87.13.5227. Proc Natl Acad Sci U S A. 1990. PMID: 2367536 Free PMC article.
-
Voltage-dependent potassium channels: minK and Shaker families.New Biol. 1991 Apr;3(4):315-23. New Biol. 1991. PMID: 2065015 Review.
-
Molecular genetic analysis of membrane protein topology.Trends Genet. 1988 Aug;4(8):223-6. doi: 10.1016/0168-9525(88)90154-0. Trends Genet. 1988. PMID: 3072723 Review. No abstract available.
Cited by
-
Opening the shaker K+ channel with hanatoxin.J Gen Physiol. 2013 Feb;141(2):203-16. doi: 10.1085/jgp.201210914. J Gen Physiol. 2013. PMID: 23359283 Free PMC article.
-
Tandem linkage of Shaker K+ channel subunits does not ensure the stoichiometry of expressed channels.Biophys J. 1992 Nov;63(5):1406-11. doi: 10.1016/S0006-3495(92)81703-4. Biophys J. 1992. PMID: 1477286 Free PMC article.
-
A family of delayed rectifier Kv1 cDNAs showing cell type-specific expression in the squid stellate ganglion/giant fiber lobe complex.J Neurosci. 1997 Jul 1;17(13):5070-9. doi: 10.1523/JNEUROSCI.17-13-05070.1997. J Neurosci. 1997. PMID: 9185544 Free PMC article.
-
Structure, function and expression of voltage-dependent sodium channels.Mol Neurobiol. 1993 Fall-Winter;7(3-4):383-428. doi: 10.1007/BF02769184. Mol Neurobiol. 1993. PMID: 8179845 Review.
-
Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle.J Gen Physiol. 1990 Jan;95(1):29-60. doi: 10.1085/jgp.95.1.29. J Gen Physiol. 1990. PMID: 2299331 Free PMC article.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
Medical
Molecular Biology Databases
