Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

doi:10.3390/ijms21145105

Review

. 2020 Jul 19;21(14):5105.

doi: 10.3390/ijms21145105.

Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

Przemysław Sitarek¹, Anna Merecz-Sadowska², Tomasz Kowalczyk³, Joanna Wieczfinska⁴, Radosław Zajdel², Tomasz Śliwiński⁵

Affiliations

¹ Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland.
² Department of Economic Informatics, University of Lodz, 90-214 Lodz, Poland.
³ Department of Molecular Biotechnology and Genetics, University of Lodz, 90-237 Lodz, Poland.
⁴ Department of Immunopathology, Medical University of Lodz, 90-752 Lodz, Poland.
⁵ Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.

PMID: 32707732
PMCID: PMC7403983
DOI: 10.3390/ijms21145105

Review

Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

Przemysław Sitarek et al. Int J Mol Sci. 2020.

. 2020 Jul 19;21(14):5105.

doi: 10.3390/ijms21145105.

Authors

Przemysław Sitarek¹, Anna Merecz-Sadowska², Tomasz Kowalczyk³, Joanna Wieczfinska⁴, Radosław Zajdel², Tomasz Śliwiński⁵

Affiliations

¹ Department of Biology and Pharmaceutical Botany, Medical University of Lodz, 90-151 Lodz, Poland.
² Department of Economic Informatics, University of Lodz, 90-214 Lodz, Poland.
³ Department of Molecular Biotechnology and Genetics, University of Lodz, 90-237 Lodz, Poland.
⁴ Department of Immunopathology, Medical University of Lodz, 90-752 Lodz, Poland.
⁵ Laboratory of Medical Genetics, Faculty of Biology and Environmental Protection, University of Lodz, 90-236 Lodz, Poland.

PMID: 32707732
PMCID: PMC7403983
DOI: 10.3390/ijms21145105

Abstract

The skin is an important organ that acts as a physical barrier to the outer environment. It is rich in immune cells such as keratinocytes, Langerhans cells, mast cells, and T cells, which provide the first line of defense mechanisms against numerous pathogens by activating both the innate and adaptive response. Cutaneous immunological processes may be stimulated or suppressed by numerous plant extracts via their immunomodulatory properties. Several plants are rich in bioactive molecules; many of these exert antimicrobial, antiviral, and antifungal effects. The present study describes the impact of plant extracts on the modulation of skin immunity, and their antimicrobial effects against selected skin invaders. Plant products remain valuable counterparts to modern pharmaceuticals and may be used to alleviate numerous skin disorders, including infected wounds, herpes, and tineas.

Keywords: immunological response; modulation of skin immunity; plant extracts; skin diseases; skin pathogens.

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Seth D., Cheldize K., Brown D., Freeman E.E. Global Burden of Skin Disease: Inequities and Innovations. Curr. Dermatol. Rep. 2017;6:204–210. doi: 10.1007/s13671-017-0192-7. - DOI - PMC - PubMed
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1. Miguel L.M.Z., Jorge M.F.S., Rocha B., Miot H.A. Incidence of skin diseases diagnosed in a public institution: Comparison between 2003 and 2014. An. Bras. Dermatol. 2017;92:423–425. doi: 10.1590/abd1806-4841.20175793. - DOI - PMC - PubMed
1. Hay R.J., Johns N.E., Williams H.C., Bolliger I.W., Dellavalle R.P., Margolis D.J., Marks R., Naldi L., Weinstock M.A., Wulf S.K., et al. The global burden of skin disease in 2010: An analysis of the prevalence and impact of skin conditions. J. Invest. Dermatol. 2014;134:1527–1534. doi: 10.1038/jid.2013.446. - DOI - PubMed
1. Natsuga K. Epidermal barriers. Cold Spring Harb. Perspect. Med. 2014;4:a018218. doi: 10.1101/cshperspect.a018218. - DOI - PMC - PubMed

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[1] Seth D., Cheldize K., Brown D., Freeman E.E. Global Burden of Skin Disease: Inequities and Innovations. Curr. Dermatol. Rep. 2017;6:204–210. doi: 10.1007/s13671-017-0192-7. - DOI - PMC - PubMed

[2] Seth D., Cheldize K., Brown D., Freeman E.E. Global Burden of Skin Disease: Inequities and Innovations. Curr. Dermatol. Rep. 2017;6:204–210. doi: 10.1007/s13671-017-0192-7. - DOI - PMC - PubMed

[3] Verhoeven E.W.M., Kraaimaat F.W., Van Weel C., Van De Kerkhof P.C.M., Duller P., Van Der Valk P.G.M., Van Den Hoogen H.J.M., Bor J.H.J., Schers H.J., Evers A.W.M. Skin diseases in family medicine: Prevalence and health care use. Ann. Fam. Med. 2008;6:349–354. doi: 10.1370/afm.861. - DOI - PMC - PubMed

[4] Verhoeven E.W.M., Kraaimaat F.W., Van Weel C., Van De Kerkhof P.C.M., Duller P., Van Der Valk P.G.M., Van Den Hoogen H.J.M., Bor J.H.J., Schers H.J., Evers A.W.M. Skin diseases in family medicine: Prevalence and health care use. Ann. Fam. Med. 2008;6:349–354. doi: 10.1370/afm.861. - DOI - PMC - PubMed

[5] Miguel L.M.Z., Jorge M.F.S., Rocha B., Miot H.A. Incidence of skin diseases diagnosed in a public institution: Comparison between 2003 and 2014. An. Bras. Dermatol. 2017;92:423–425. doi: 10.1590/abd1806-4841.20175793. - DOI - PMC - PubMed

[6] Miguel L.M.Z., Jorge M.F.S., Rocha B., Miot H.A. Incidence of skin diseases diagnosed in a public institution: Comparison between 2003 and 2014. An. Bras. Dermatol. 2017;92:423–425. doi: 10.1590/abd1806-4841.20175793. - DOI - PMC - PubMed

[7] Hay R.J., Johns N.E., Williams H.C., Bolliger I.W., Dellavalle R.P., Margolis D.J., Marks R., Naldi L., Weinstock M.A., Wulf S.K., et al. The global burden of skin disease in 2010: An analysis of the prevalence and impact of skin conditions. J. Invest. Dermatol. 2014;134:1527–1534. doi: 10.1038/jid.2013.446. - DOI - PubMed

[8] Hay R.J., Johns N.E., Williams H.C., Bolliger I.W., Dellavalle R.P., Margolis D.J., Marks R., Naldi L., Weinstock M.A., Wulf S.K., et al. The global burden of skin disease in 2010: An analysis of the prevalence and impact of skin conditions. J. Invest. Dermatol. 2014;134:1527–1534. doi: 10.1038/jid.2013.446. - DOI - PubMed

[9] Natsuga K. Epidermal barriers. Cold Spring Harb. Perspect. Med. 2014;4:a018218. doi: 10.1101/cshperspect.a018218. - DOI - PMC - PubMed

[10] Natsuga K. Epidermal barriers. Cold Spring Harb. Perspect. Med. 2014;4:a018218. doi: 10.1101/cshperspect.a018218. - DOI - PMC - PubMed

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Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

Affiliations

Potential Synergistic Action of Bioactive Compounds from Plant Extracts against Skin Infecting Microorganisms

Authors

Affiliations

Abstract

Conflict of interest statement

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References

Publication types

MeSH terms

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LinkOut - more resources

Full Text Sources

Medical