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. 2020 Jul 24;15(7):e0236858.
doi: 10.1371/journal.pone.0236858. eCollection 2020.

Quantitative lung lesion features and temporal changes on chest CT in patients with common and severe SARS-CoV-2 pneumonia

Yue Zhang  1 , Ying Liu  2 , Honghan Gong  3 , Lin Wu  3
Affiliations

Quantitative lung lesion features and temporal changes on chest CT in patients with common and severe SARS-CoV-2 pneumonia

Yue Zhang et al. PLoS One. .

Abstract

The purpose of this study was to describe the temporal evolution of quantitative lung lesion features on chest computed tomography (CT) in patients with common and severe types of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia. Records of patients diagnosed with SARS-CoV-2 pneumonia were reviewed retrospectively from 24 January 2020 to 15 March 2020. Patients were classified into common and severe groups according to the diagnostic criteria of severe pneumonia. The quantitative CT features of lung lesions were automatically calculated using artificial intelligence algorithms, and the percentages of ground-glass opacity volume (PGV), consolidation volume (PCV) and total lesion volume (PTV) were determined in both lungs. PGV, PCV and PTV were analyzed based on the time from the onset of initial symptoms in the common and severe groups. In the common group, PTV increased slowly and peaked at approximately 12 days from the onset of the initial symptoms. In the severe group, PTV peaked at approximately 17 days. The severe pneumonia group exhibited increased PGV, PCV and PTV compared with the common group. These features started to appear in Stage 2 (4-7 days from onset of initial symptoms) and were observed in all subsequent stages (p<0.05). In severe SARS-CoV-2 pneumonia patients, PGV, PCV and PTV began to significantly increase in Stage 2 and decrease in Stage 5 (22-30 days). Compared with common SARS-CoV-2 pneumonia patients, the patients in the severe group exhibited increased PGV, PCV and PTV as well as a later peak time of lesion and recovery time.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Fig 1
Fig 1. Changes in PTV, PCV and PTV on chest CT from time of onset of initial symptoms (days).
Temporal changes in PTV (a), PGV (b) and PCV (c) for each patient. Fitted curve is depicted in each graph. PGV, percentage of ground-glass opacity volume; PCV, percentage of consolidation volume; PTV, percentage of total pneumonia lesion volume.
See this image and copyright information in PMC

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Grants and funding

This study was supported by the Natural Science Foundation of Jiangxi, China (Grant no. 2017BAB215048), the Science and Technology Project of Jiangxi Health Committee (Grant no. 20181020), and the Science and Technology Research Project of Jiangxi Provincial Department of Education (Grant no. 700993003).