Osteosarcopenia: beyond age-related muscle and bone loss

doi:10.1007/s41999-020-00355-6

Review

. 2020 Oct;11(5):715-724.

doi: 10.1007/s41999-020-00355-6. Epub 2020 Jul 16.

Osteosarcopenia: beyond age-related muscle and bone loss

Gabriela Fagundes Belchior¹, Ben Kirk^{2

3}, Evela Aparecida Pereira da Silva⁴, Gustavo Duque^{5

6}

Affiliations

¹ Albert Einstein Hospital, São Paulo, Brazil.
² Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Melbourne, VIC, Australia.
³ Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, 176 Furlong Road, St Albans, Melbourne, VIC, 3121, Australia.
⁴ Universidade Federal do Estado de São Paulo, Unifesp, São Paulo, Brazil.
⁵ Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Melbourne, VIC, Australia. gustavo.duque@unimelb.edu.au.
⁶ Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, 176 Furlong Road, St Albans, Melbourne, VIC, 3121, Australia. gustavo.duque@unimelb.edu.au.

PMID: 32676865
DOI: 10.1007/s41999-020-00355-6

Review

Osteosarcopenia: beyond age-related muscle and bone loss

Gabriela Fagundes Belchior et al. Eur Geriatr Med. 2020 Oct.

. 2020 Oct;11(5):715-724.

doi: 10.1007/s41999-020-00355-6. Epub 2020 Jul 16.

Authors

Gabriela Fagundes Belchior¹, Ben Kirk^{2

3}, Evela Aparecida Pereira da Silva⁴, Gustavo Duque^{5

6}

Affiliations

¹ Albert Einstein Hospital, São Paulo, Brazil.
² Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Melbourne, VIC, Australia.
³ Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, 176 Furlong Road, St Albans, Melbourne, VIC, 3121, Australia.
⁴ Universidade Federal do Estado de São Paulo, Unifesp, São Paulo, Brazil.
⁵ Department of Medicine-Western Health, Melbourne Medical School, University of Melbourne, St Albans, Melbourne, VIC, Australia. gustavo.duque@unimelb.edu.au.
⁶ Australian Institute for Musculoskeletal Science (AIMSS), University of Melbourne and Western Health, 176 Furlong Road, St Albans, Melbourne, VIC, 3121, Australia. gustavo.duque@unimelb.edu.au.

PMID: 32676865
DOI: 10.1007/s41999-020-00355-6

Abstract

Purpose: Osteosarcopenia is a geriatric syndrome characterized by declines in bone density and microarchitecture and muscle mass and strength, which has gained clinical interest due to its association with falls and fragility fractures.

Methods: This review discusses the epidemiology of osteosarcopenia including clinical assessment, the pathophysiological aspects leading to the loss of muscle and bone mass, and efficacious therapeutic strategies to combat this syndrome.

Results: The etiology of osteosarcopenia is thought to include genetic and environmental factors which interact with muscle and bone at the cellular level, reinforcing that these tissues are interconnected not only by mechanical aspects, but also by humoral factors. Osteosarcopenia is identified by low muscle and bone mass and impaired strength of these tissues via imaging and physical performance measures.

Conclusion: The diagnosis of osteosarcopenia is of clinical importance since early interventions, particularly resistance exercise, and adequate intake of protein, vitamin D and calcium, may delay the onset of individual components (osteopenia/sarcopenia) of osteosarcopenia.

Keywords: Aging; Geroscience; Osteoporosis; Osteosarcopenia; Sarcopenia.

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Osteosarcopenia: beyond age-related muscle and bone loss

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Osteosarcopenia: beyond age-related muscle and bone loss

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