Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1988 Nov;85(21):8221-5.
doi: 10.1073/pnas.85.21.8221.

Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression

J Ohara  1 , W E Paul
Affiliations

Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression

J Ohara et al. Proc Natl Acad Sci U S A. 1988 Nov.

Abstract

The expression of interleukin 4 (IL-4) receptors on resting T and B lymphocytes was enhanced 4- to 8-fold by IL-4 stimulation of these cells. Other agents such as lipopolysaccharide and anti-IgM for B cells and concanavalin A for T cells also caused increased IL-4 receptor expression, although to a somewhat smaller degree than IL-4. Using a newly developed flow cytometric analysis based on the binding of biotinylated IL-4 and phycoerythrin-streptavidin, it was observed that receptor up-regulation in a T-cell population treated with IL-4 was a feature of the majority of the T cells. Analysis of IL-4 by cross-linkage of 125I-labeled IL-4 to IL-4 receptor with disuccinimidyl suberate indicated that the IL-4-IL-4 receptor complex was the same size in the resting and up-regulated cells, implying that the same receptor species found in resting cells was up-regulated in response to IL-4.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Proc Natl Acad Sci U S A. 1986 Apr;83(7):2061-5 - PubMed
    1. Nature. 1986 Feb 20-26;319(6055):640-6 - PubMed
    1. J Exp Med. 1986 Aug 1;164(2):517-31 - PubMed
    1. Proc Natl Acad Sci U S A. 1986 Aug;83(16):5894-8 - PubMed
    1. J Exp Med. 1987 Jan 1;165(1):157-72 - PubMed

LinkOut - more resources