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. 2020 Jun 5;7(6):ofaa220.
doi: 10.1093/ofid/ofaa220. eCollection 2020 Jun.

Secondary Bacterial Infections in Critical Ill Patients With Coronavirus Disease 2019

Yiqi Fu  1 , Qing Yang  2   3   4 , Min Xu  2   3 , Haishen Kong  2   3   4 , Hongchao Chen  2   3 , Yajie Fu  2   3 , Yake Yao  1 , Hua Zhou  1 , Jianying Zhou  1
Affiliations

Secondary Bacterial Infections in Critical Ill Patients With Coronavirus Disease 2019

Yiqi Fu et al. Open Forum Infect Dis. .

Abstract

Secondary bacterial infections occurred in 13.9% (5 of 36) of critical ill patients with coronavirus disease 2019. All 5 patients had been admitted to intensive care unit and received mechanical ventilation before developing bacterial infection. Active surveillance of culture should be performed for critically ill patients. Prevention of nosocomial infection should to be taken seriously.

Keywords: COVID-19; Gram-negative bacilli; antibiotic prophylaxis; bacterial infection; critical ill.

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Figures

Figure 1.
Figure 1.
Timelines of the 5 patients with coronavirus disease 2019 and secondary bacterial coinfection. Vertical bars and colored texts indicate isolated times, samples, and organisms. A. fumigatus, Aspergillus fumigatus; B. cepacia, Burkholderia cepacia; BALF, bronchoalveolar lavage fluid; C. albicans, Candida albicans; CAZ/AVI, ceftazidime/avibactam; CRO, ceftriaxone; CXM, cefuroxime; E. coli, Escherichia coli; IMP, imipenem; K. pneumoniae, Klebsiella pneumoniae; MXF, moxifloxacin; P. aeruginosa, Pseudomonas aeruginosa; S. maltophilia, Stenotrophomonas maltophilia; SCF, cefoperazone/sulbactam; TA, tracheal aspirate; TZP, piperacillin/tazobactam; VAN, vancomycin.
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