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Review
. 2020 Oct;50(10):e13334.
doi: 10.1111/eci.13334. Epub 2020 Jul 22.

Implications of NAD+ boosters in translational medicine

Baeki E Kang  1 , Jun-Yong Choi  2 , Sokrates Stein  3   4 , Dongryeol Ryu  1   5   6
Affiliations
Review

Implications of NAD+ boosters in translational medicine

Baeki E Kang et al. Eur J Clin Invest. 2020 Oct.

Abstract

Nicotinamide adenine dinucleotide (NAD+ ) is an essential metabolite in energy metabolism as well as a co-substrate in biochemical reactions such as protein deacylation, protein ADP-ribosylation and cyclic ADP-ribose synthesis mediated by sirtuins, poly (ADP-ribose) polymerases (PARPs) and CD38. In eukaryotic cells, NAD+ is synthesized through three distinct pathways, which offer different strategies to modulate the bioavailability of NAD+ . The therapeutic potential of dietarily available NAD+ boosters preserving the NAD+ pool has been attracting attention after the discovery of declining NAD+ levels in ageing model organisms as well as in several age-related diseases, including cardiometabolic and neurodegenerative diseases. Here, we review the recent advances in the biology of NAD+ , including the salubrious effects of NAD+ boosters and discuss their future translational strategies.

Keywords: NAD+ booster; ageing; nicotinamide adenine dinucleotide (NAD+); nicotinamide riboside (NR).

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References

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