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. 2020 Jun;48(6):300060520926020.
doi: 10.1177/0300060520926020.

Association of dyslipidaemia with Alzheimer's disease in a cohort of postmenopausal women

Ning Li  1 , Xiaoying Xu  2 , Shuai Mao  3 , Ye Jiang  1 , Yadong Hu  1 , Ruowei Xing  1 , Yajing Chen  1 , Junxing Ye  4 , Li Ling  1 , Xianshang Zeng  5 , Guowei Han  5
Affiliations

Association of dyslipidaemia with Alzheimer's disease in a cohort of postmenopausal women

Ning Li et al. J Int Med Res. 2020 Jun.

Abstract

Objective: To evaluate the association between dyslipidaemia and Alzheimer's disease (AD) in a cohort of postmenopausal women.

Methods: This retrospective study analysed data from postmenopausal women with early AD (group AD) and a cohort of healthy age- and sex-matched control subjects (group NC) that were considered to be within standard limits according to a neuropsychological assessment between March 2010 and March 2019. The primary endpoints were body mass index and lipid-related laboratory parameters, including leptin, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol, adiponectin, triglycerides, apolipoprotein A1, apolipoprotein B and apolipoprotein E4, which were evaluated using multivariate binary logistic analysis.

Results: The study enrolled 200 postmenopausal women with early AD (mean ± SD age 69.34 ± 6.25 years) and 180 control subjects (mean ± SD age 67.48 ± 7.42 years). Lower HDL-C and higher LDL-C were risk factors for AD. A multivariate binary logistic regression model demonstrated that lower HDL-C and higher LDL-C were the only variables associated with the development of AD (odds ratio [OR] 21.14, 95% confidence interval [CI] 2.47, 4.13; OR 36.35, 95% CI 1.24, 3.38; respectively).

Conclusion: Both low HDL-C and high LDL-C were associated with the occurrence of AD in a cohort of postmenopausal women.

Keywords: Alzheimer’s disease; Dyslipidaemia; association; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol; postmenopausal.

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Figures

Figure 1.
Figure 1.
Flow diagram demonstrating the identification, exclusion and recruitment of a cohort of postmenopausal women with early Alzheimer’s disease (AD) in a study that aimed to evaluate the association between dyslipidaemia and AD. Group NC, healthy control subjects.
See this image and copyright information in PMC

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