Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2020 Jul;49(6):580-589.
doi: 10.1111/jop.13078. Epub 2020 Jul 4.

Molecular mechanisms of painful traumatic trigeminal neuropathy-Evidence from animal research and clinical correlates

Olga A Korczeniewska  1 , Junad Khan  2 , Eli Eliav  2 , Rafael Benoliel  1
Affiliations
Review

Molecular mechanisms of painful traumatic trigeminal neuropathy-Evidence from animal research and clinical correlates

Olga A Korczeniewska et al. J Oral Pathol Med. 2020 Jul.

Abstract

Painful traumatic trigeminal neuropathy (PTTN) may occur following major craniofacial or oral trauma, or may be subsequent to relatively minor dental interventions. Following injury, pain may originate from a peripheral nerve, a ganglion, or from the central nervous system. In this review, we focus on molecular mechanisms of pain resulting from injury to the peripheral branch of the trigeminal nerve. This syndrome has been termed painful traumatic trigeminal neuropathy (PTTN) by the International Headache Society and replaces previous terms including atypical odontalgia, deafferentation pain, traumatic neuropathy and phantom toothache. We emphasize the scientific evidence supporting the events purported to lead to PTTN by reviewing the pathophysiology of PTTN based on relevant animal models. Additionally, we briefly overview clinical correlates and pathophysiological manifestations of PTTN.

Keywords: neuropathic pain; painful traumatic trigeminal neuropathy; pathophysiology; trauma.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

REFERENCES

    1. Haanpaa M, Attal N, Backonja M, et al. NeuPSIG guidelines on neuropathic pain assessment. Pain. 2011;152:14-27.
    1. Elad S, Sroussi H, Klasser GD, et al. Secondary orofacial pain and headache: Systemic diseases, tumors, and trauma. In: Sharav Y, Benoliel R (Eds.), Orofacial Pain & Headache. Berlin, Germany: Quintessence International, 2015; 487-540.
    1. Benoliel R, Heir G, Eliav E. Neuropathic orofacial pain. In: Sharav Y, Benoliel R (Eds.), Orofacial Pain & Headache. Berlin, Germany: Quintessence International, 2015; 407-474.
    1. Headache Classification Subcommittee of the International Headache Society (IHS). The International Classification of Headache Disorders, 3rd Edition (beta version). Cephalalgia. 2013;33:629-808.
    1. Smith JH, Cutrer FM. Numbness matters: a clinical review of trigeminal neuropathy. Cephalalgia. 2011;31:1131-1144.

LinkOut - more resources