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Review
. 2021 Jan;236(1):49-54.
doi: 10.1002/jcp.29868. Epub 2020 Jun 15.

An updated review of the association of host genetic factors with susceptibility and resistance to COVID-19

Somayeh Mohammadpour  1 , Amir Torshizi Esfahani  2 , Mehrdad Halaji  3 , Mina Lak  4 , Reza Ranjbar  5
Affiliations
Review

An updated review of the association of host genetic factors with susceptibility and resistance to COVID-19

Somayeh Mohammadpour et al. J Cell Physiol. 2021 Jan.

Abstract

The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human populations sparked a global pandemic of the coronavirus disease 2019 (COVID-19). According to preliminary data, about 14% of cases are considered severe and 5% of cases result in critical illness and, reported case fatality rates vary from 1% to more than 7%. However, the symptoms of the disease and the clinical outcome are very different in infected people. In view of these differences, it is clearly apparent that to gain insight into the biology of the SARS-CoV-2, it is important to study not just the infectious particle in itself but also to investigate the virus-host cell interactions that occur during infection. This review seeks to consider the various aspects of genetic factors in determining the susceptibility and host resistance to SARS-CoV-2 throughout the recently published literature.

Keywords: COVID-19; SARS-CoV-2; genetics; resistance; susceptibility.

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Conflict of interest statement

The authors declare that there are no conflict of interests.

Figures

Figure 1
Figure 1
Schematic representation of the overall genome and protein of SARS‐CoV‐2 and host cell receptors and inhibitors. (a) Linear representation of the SARS‐CoV‐2 genome and the Spike protein. (b) Spike proteins on the surface of the SARS‐CoV‐2 bind to ACE‐2, TMPRSS2, GRP78, and CD147. The suggested inhibitor for each receptor is indicated. ACE2, angiotensin‐converting enzyme 2; CD147, cluster of differentiation 147; GRP78, glucose‐regulated protein 78 kDa; SARS‐CoV‐2, severe acute respiratory syndrome coronavirus 2; TMPRSS2, transmembrane protease serine‐type 2
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